Abstract
Nano-dagger coated gauze was bactericidal against both Gram-positive and Gram-negative bacteria, with log reduction >7 for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Compared with the commercially available Ag gauze, the ZIF-L nano-dagger coated gauze was more biocompatible with a lower haemolytic activity, less cytotoxicity and improved wound healing performance. Animal studies showed that the ZIF-L coated gauze can effectively kill bacteria in a S. aureus wound infection model in mice. This novel nano-dagger coated gauze offers an effective and safe alternative for patients to protect against wound infections. This study demonstrates the first application of a MOF coating as an antibiotic-free wound dressing with potent antimicrobial activity and improved biocompatibility.
| Original language | English |
|---|---|
| Pages (from-to) | 699-702 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 55 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2019 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© The Royal Society of Chemistry.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Catalysis
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry