Abstract
Vernonione, a new 7-deoxycarvotacetone derivative 1, together with three known sesquiterpene lactones; vernolide A, C (2,3) and potamopholide (4) has been isolated from the methanolic extract of the roots of Vernonia cinerascens. The structure 3β-acetoxy-5α-angeloyloxy- 7-deoxycarvotacetone was established by using UV, IR, 1H and 13C-NMR spectra (DEPT), 2D-NMR analyses (COSY, HMQC and HMBC experiments) in combination with HRFAB-MS, HREI-MS experiments and in comparison with literature data of related compounds. Compound 1 showed inhibitory potential against enzyme urease in concentration dependant fashion with IC50 value 227.6 μmol.
| Original language | English |
|---|---|
| Pages (from-to) | 639-642 |
| Number of pages | 4 |
| Journal | Journal of the Chemical Society of Pakistan |
| Volume | 34 |
| Issue number | 3 |
| State | Published - Jun 2012 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Chemistry
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