Valorization of Syzygium cumini Leaves to Produce Silver Nanoparticles for Efficient Anticancer, Antidiabetic and Antioxidant Potential

Nanotechnology gained much attention of scientists due to their distinctive physicochemical characteristics. The purpose of this study is to examine the biogenic production of silver nanoparticles (AgNPs) using the biological extract of Syzygium cumini a well-known medicinal plant that cure various ailments and investigate its therapeutic potential. Confirmation of silver NPs was done by examining the absorption spectra of silver nanoparticles, significant peak was observed at a wavelength of 450nm. Scanning electron microscope results revealed spherical shaped AgNPs in cluster form with slight agglomeration. The FTIR revels various functional groups that present in plant extract and X-ray diffraction analysis showed crystalline size of ~ 47nm. The AgNPs demonstrated antiproliferative activities against HepG2, Huh-7 (human liver), A-549 (human lung) and MCF-7 (human breast) cancer cell line with 84.3, 56.1, 47.4 and 61.5% inhibition respectively at an optimum concentration of 50 µg/mL. The antidiabetic assay revealed 54.6% inhibition of α-glucosidase enzyme at an optimum concentration of 50 µg/mL. The study also revealed that super optimal concentration might have adverse effect in inhibiting cancer cell proliferation and α-glucosidase enzyme. This study paves the way for Syzygium cumini mediated AgNPs to be useful therapeutic agents in the field of health care and medicine to cure various diseases.