Using cerium (III) orthovanadate as an efficient catalyst for the electrochemical sensing of anti-prostate cancer drug (flutamide) in biological fluids

Muthumariappan Akilarasan; Selvarasu Maheshwaran; Tse Wei Chen; Shen Ming Chen; Elayappan Tamilalagan; M. Ajmal Ali; Wedad A. Al-onazi; Amal M. Al-Mohaimeed

doi:10.1016/j.microc.2020.105509

Using cerium (III) orthovanadate as an efficient catalyst for the electrochemical sensing of anti-prostate cancer drug (flutamide) in biological fluids

Muthumariappan Akilarasan
, Selvarasu Maheshwaran
, Tse Wei Chen
, Shen Ming Chen^*
, Elayappan Tamilalagan
, M. Ajmal Ali
, Wedad A. Al-onazi
, Amal M. Al-Mohaimeed

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Herein, we reported the synthesis of cerium orthovanadate nanorods (CeVO₄-NRs) using the hydrothermal methodology and its excellent performance towards the detection of anti-prostate cancer drug flutamide (FLA) sensing in biological samples. The size and structural properties of the as-prepared CeVO₄-NRs was characterized through the FESEM and HRTEM. Moreover, the optical properties and chemical composition of the CeVO₄-NRs was configured by the Fourier transform infrared spectroscopy (FTIR), UV–Vis spectrophotometer, XRD and Raman spectroscopy. The electrocatalytic activity of CeVO₄-NRs towards the detection of FLA was scrutinized through cyclic voltammetry (CV) and DPV techniques. Besides, the fabricated sensor possessed the covering range of 0.01to 57 µM and 75.26 to 507.94 µM with a lower detection limit of 1.94 nM. At the end, the FLA detection in real samples of human blood serum and urine samples at CeVO₄-NRs/GCE exhibited acceptable found and recovery values.

Original language	English
Article number	105509
Journal	Microchemical Journal
Volume	159
DOIs	https://doi.org/10.1016/j.microc.2020.105509
State	Published - Dec 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier B.V.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biological samples
CeVO
Electrochemical sensor
Flutamide sensor
Hydrothermal method

ASJC Scopus subject areas

Analytical Chemistry
Spectroscopy

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Akilarasan, M., Maheshwaran, S., Chen, T. W., Chen, S. M., Tamilalagan, E., Ajmal Ali, M., Al-onazi, W. A., & Al-Mohaimeed, A. M. (2020). Using cerium (III) orthovanadate as an efficient catalyst for the electrochemical sensing of anti-prostate cancer drug (flutamide) in biological fluids. Microchemical Journal, 159, Article 105509. https://doi.org/10.1016/j.microc.2020.105509

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title = "Using cerium (III) orthovanadate as an efficient catalyst for the electrochemical sensing of anti-prostate cancer drug (flutamide) in biological fluids",

abstract = "Herein, we reported the synthesis of cerium orthovanadate nanorods (CeVO4-NRs) using the hydrothermal methodology and its excellent performance towards the detection of anti-prostate cancer drug flutamide (FLA) sensing in biological samples. The size and structural properties of the as-prepared CeVO4-NRs was characterized through the FESEM and HRTEM. Moreover, the optical properties and chemical composition of the CeVO4-NRs was configured by the Fourier transform infrared spectroscopy (FTIR), UV–Vis spectrophotometer, XRD and Raman spectroscopy. The electrocatalytic activity of CeVO4-NRs towards the detection of FLA was scrutinized through cyclic voltammetry (CV) and DPV techniques. Besides, the fabricated sensor possessed the covering range of 0.01to 57 µM and 75.26 to 507.94 µM with a lower detection limit of 1.94 nM. At the end, the FLA detection in real samples of human blood serum and urine samples at CeVO4-NRs/GCE exhibited acceptable found and recovery values.",

keywords = "Biological samples, CeVO, Electrochemical sensor, Flutamide sensor, Hydrothermal method",

author = "Muthumariappan Akilarasan and Selvarasu Maheshwaran and Chen, \{Tse Wei\} and Chen, \{Shen Ming\} and Elayappan Tamilalagan and \{Ajmal Ali\}, M. and Al-onazi, \{Wedad A.\} and Al-Mohaimeed, \{Amal M.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = dec,

doi = "10.1016/j.microc.2020.105509",

language = "English",

volume = "159",

journal = "Microchemical Journal",

issn = "0026-265X",

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TY - JOUR

T1 - Using cerium (III) orthovanadate as an efficient catalyst for the electrochemical sensing of anti-prostate cancer drug (flutamide) in biological fluids

AU - Akilarasan, Muthumariappan

AU - Maheshwaran, Selvarasu

AU - Chen, Tse Wei

AU - Chen, Shen Ming

AU - Tamilalagan, Elayappan

AU - Ajmal Ali, M.

AU - Al-onazi, Wedad A.

AU - Al-Mohaimeed, Amal M.

PY - 2020/12

Y1 - 2020/12

N2 - Herein, we reported the synthesis of cerium orthovanadate nanorods (CeVO4-NRs) using the hydrothermal methodology and its excellent performance towards the detection of anti-prostate cancer drug flutamide (FLA) sensing in biological samples. The size and structural properties of the as-prepared CeVO4-NRs was characterized through the FESEM and HRTEM. Moreover, the optical properties and chemical composition of the CeVO4-NRs was configured by the Fourier transform infrared spectroscopy (FTIR), UV–Vis spectrophotometer, XRD and Raman spectroscopy. The electrocatalytic activity of CeVO4-NRs towards the detection of FLA was scrutinized through cyclic voltammetry (CV) and DPV techniques. Besides, the fabricated sensor possessed the covering range of 0.01to 57 µM and 75.26 to 507.94 µM with a lower detection limit of 1.94 nM. At the end, the FLA detection in real samples of human blood serum and urine samples at CeVO4-NRs/GCE exhibited acceptable found and recovery values.

AB - Herein, we reported the synthesis of cerium orthovanadate nanorods (CeVO4-NRs) using the hydrothermal methodology and its excellent performance towards the detection of anti-prostate cancer drug flutamide (FLA) sensing in biological samples. The size and structural properties of the as-prepared CeVO4-NRs was characterized through the FESEM and HRTEM. Moreover, the optical properties and chemical composition of the CeVO4-NRs was configured by the Fourier transform infrared spectroscopy (FTIR), UV–Vis spectrophotometer, XRD and Raman spectroscopy. The electrocatalytic activity of CeVO4-NRs towards the detection of FLA was scrutinized through cyclic voltammetry (CV) and DPV techniques. Besides, the fabricated sensor possessed the covering range of 0.01to 57 µM and 75.26 to 507.94 µM with a lower detection limit of 1.94 nM. At the end, the FLA detection in real samples of human blood serum and urine samples at CeVO4-NRs/GCE exhibited acceptable found and recovery values.

KW - Biological samples

KW - CeVO

KW - Electrochemical sensor

KW - Flutamide sensor

KW - Hydrothermal method

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DO - 10.1016/j.microc.2020.105509

M3 - Article

AN - SCOPUS:85091524362

SN - 0026-265X

VL - 159

JO - Microchemical Journal

JF - Microchemical Journal

M1 - 105509

ER -

Using cerium (III) orthovanadate as an efficient catalyst for the electrochemical sensing of anti-prostate cancer drug (flutamide) in biological fluids

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

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