Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug

Stavroula Nanaki; Maria Tseklima; Zoe Terzopoulou; Maria Nerantzaki; Dimitrios J. Giliopoulos; Konstantinos Triantafyllidis; Margaritis Kostoglou; Dimitrios N. Bikiaris

doi:10.1016/j.ejpb.2017.03.016

Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug

Stavroula Nanaki, Maria Tseklima, Zoe Terzopoulou, Maria Nerantzaki, Dimitrios J. Giliopoulos, Konstantinos Triantafyllidis, Margaritis Kostoglou, Dimitrios N. Bikiaris^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

In this study, high surface area mesoporous silica foam with cellular pore morphology (MCF) was used for injectable delivery of paliperidone, an antipsychotic drug used in patients suffering from bipolar disorder. The aim was to enhance paliperidone solubility and simultaneously to prepare long active intractable microspheres. For this reason paliperidone was first loaded in MCF silica, and the whole system was further encapsulated into PLA and PLGA 75/25 w/w copolymer in the form of microspheres. It was found that paliperidone, after its adsorption into MCF, was transformed in its amorphous state, thus leading to enhanced in vitro dissolution profile. Furthermore, incorporation of the drug-loaded MCF to polymeric microparticles (PLA and PLGA) prolonged the release time of paliperidone from 10 to 15 days.

Original language	English
Pages (from-to)	77-90
Number of pages	14
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	117
DOIs	https://doi.org/10.1016/j.ejpb.2017.03.016
State	Published - 1 Aug 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

Antipsychotic drug
Long acting injectable
Mesoporous cellular foam (MCF)
Microspheres
PLA
PLGA
Paliparidone

ASJC Scopus subject areas

Biotechnology
Pharmaceutical Science

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10.1016/j.ejpb.2017.03.016

Cite this

Nanaki, S., Tseklima, M., Terzopoulou, Z., Nerantzaki, M., Giliopoulos, D. J., Triantafyllidis, K., Kostoglou, M., & Bikiaris, D. N. (2017). Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug. European Journal of Pharmaceutics and Biopharmaceutics, 117, 77-90. https://doi.org/10.1016/j.ejpb.2017.03.016

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title = "Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug",

abstract = "In this study, high surface area mesoporous silica foam with cellular pore morphology (MCF) was used for injectable delivery of paliperidone, an antipsychotic drug used in patients suffering from bipolar disorder. The aim was to enhance paliperidone solubility and simultaneously to prepare long active intractable microspheres. For this reason paliperidone was first loaded in MCF silica, and the whole system was further encapsulated into PLA and PLGA 75/25 w/w copolymer in the form of microspheres. It was found that paliperidone, after its adsorption into MCF, was transformed in its amorphous state, thus leading to enhanced in vitro dissolution profile. Furthermore, incorporation of the drug-loaded MCF to polymeric microparticles (PLA and PLGA) prolonged the release time of paliperidone from 10 to 15 days.",

keywords = "Antipsychotic drug, Long acting injectable, Mesoporous cellular foam (MCF), Microspheres, PLA, PLGA, Paliparidone",

author = "Stavroula Nanaki and Maria Tseklima and Zoe Terzopoulou and Maria Nerantzaki and Giliopoulos, \{Dimitrios J.\} and Konstantinos Triantafyllidis and Margaritis Kostoglou and Bikiaris, \{Dimitrios N.\}",

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doi = "10.1016/j.ejpb.2017.03.016",

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Nanaki, S, Tseklima, M, Terzopoulou, Z, Nerantzaki, M, Giliopoulos, DJ, Triantafyllidis, K, Kostoglou, M & Bikiaris, DN 2017, 'Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug', European Journal of Pharmaceutics and Biopharmaceutics, vol. 117, pp. 77-90. https://doi.org/10.1016/j.ejpb.2017.03.016

Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug. / Nanaki, Stavroula; Tseklima, Maria; Terzopoulou, Zoe et al.
In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 117, 01.08.2017, p. 77-90.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug

AU - Nanaki, Stavroula

AU - Tseklima, Maria

AU - Terzopoulou, Zoe

AU - Nerantzaki, Maria

AU - Giliopoulos, Dimitrios J.

AU - Triantafyllidis, Konstantinos

AU - Kostoglou, Margaritis

AU - Bikiaris, Dimitrios N.

PY - 2017/8/1

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AB - In this study, high surface area mesoporous silica foam with cellular pore morphology (MCF) was used for injectable delivery of paliperidone, an antipsychotic drug used in patients suffering from bipolar disorder. The aim was to enhance paliperidone solubility and simultaneously to prepare long active intractable microspheres. For this reason paliperidone was first loaded in MCF silica, and the whole system was further encapsulated into PLA and PLGA 75/25 w/w copolymer in the form of microspheres. It was found that paliperidone, after its adsorption into MCF, was transformed in its amorphous state, thus leading to enhanced in vitro dissolution profile. Furthermore, incorporation of the drug-loaded MCF to polymeric microparticles (PLA and PLGA) prolonged the release time of paliperidone from 10 to 15 days.

KW - Antipsychotic drug

KW - Long acting injectable

KW - Mesoporous cellular foam (MCF)

KW - Microspheres

KW - PLA

KW - PLGA

KW - Paliparidone

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VL - 117

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EP - 90

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

ER -

Use of mesoporous cellular foam (MCF) in preparation of polymeric microspheres for long acting injectable release formulations of paliperidone antipsychotic drug

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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