Tuning the Morphology of Au/ZnO Nanocomposite Using Pulsed Laser Ablation for Anticancer Applications

Muidh Alheshibri; Khaled A. Elsayed; Firdos Alam Khan; Shamsuddeen A. Haladu; Filiz Ercan; Emre Çevik; Q. A. Drmosh; T. S. Kayed; M. A. Almessiere

doi:10.1007/s13369-023-08061-8

Tuning the Morphology of Au/ZnO Nanocomposite Using Pulsed Laser Ablation for Anticancer Applications

Muidh Alheshibri^*, Khaled A. Elsayed^*, Firdos Alam Khan, Shamsuddeen A. Haladu, Filiz Ercan, Emre Çevik, Q. A. Drmosh, T. S. Kayed, M. A. Almessiere

^*Corresponding author for this work

Interdisciplinary Research Center for Hydrogen Technologies and Carbon Management

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Developing a nanosized platform for annihilating cancer cells is highly promising and desirable in the field of nanomedicine especially when an eco-friendly synthesis protocol such as laser ablation is employed. Herein, pulsed laser ablation technique was used to fabricate Au/ZnO nanocomposite in deionized water. The prepared nanostructures were examined using HRTEM, SEM, EDX, XRD, UV–Vis, and Raman spectroscopy. An in vitro cytotoxicity evaluation of the prepared Au/ZnO nanocomposite on human colorectal carcinoma HCT116 and cervical cancer HeLa cells reveals the strong inhibitory action of the nanomaterials on the cancer cells. The influence of the nanocomposites on healthy HEK-293 cell line used as a control was minimal. The outcomes of this work mark the merits of laser ablation in the fabrication of highly pure nanomaterials with good efficacy against cancer cells.

Original language	English
Pages (from-to)	1063-1074
Number of pages	12
Journal	Arabian Journal for Science and Engineering
Volume	49
Issue number	1
DOIs	https://doi.org/10.1007/s13369-023-08061-8
State	Published - Jan 2024

Bibliographical note

Publisher Copyright:
© 2023, King Fahd University of Petroleum & Minerals.

Keywords

Anticancer activity
Gold nanoparticles
Laser ablation
Zinc oxide nanoparticles

ASJC Scopus subject areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13369-023-08061-8

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title = "Tuning the Morphology of Au/ZnO Nanocomposite Using Pulsed Laser Ablation for Anticancer Applications",

abstract = "Developing a nanosized platform for annihilating cancer cells is highly promising and desirable in the field of nanomedicine especially when an eco-friendly synthesis protocol such as laser ablation is employed. Herein, pulsed laser ablation technique was used to fabricate Au/ZnO nanocomposite in deionized water. The prepared nanostructures were examined using HRTEM, SEM, EDX, XRD, UV–Vis, and Raman spectroscopy. An in vitro cytotoxicity evaluation of the prepared Au/ZnO nanocomposite on human colorectal carcinoma HCT116 and cervical cancer HeLa cells reveals the strong inhibitory action of the nanomaterials on the cancer cells. The influence of the nanocomposites on healthy HEK-293 cell line used as a control was minimal. The outcomes of this work mark the merits of laser ablation in the fabrication of highly pure nanomaterials with good efficacy against cancer cells.",

keywords = "Anticancer activity, Gold nanoparticles, Laser ablation, Zinc oxide nanoparticles",

author = "Muidh Alheshibri and Elsayed, {Khaled A.} and Khan, {Firdos Alam} and Haladu, {Shamsuddeen A.} and Filiz Ercan and Emre {\c C}evik and Drmosh, {Q. A.} and Kayed, {T. S.} and Almessiere, {M. A.}",

note = "Publisher Copyright: {\textcopyright} 2023, King Fahd University of Petroleum & Minerals.",

year = "2024",

month = jan,

doi = "10.1007/s13369-023-08061-8",

language = "English",

volume = "49",

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T1 - Tuning the Morphology of Au/ZnO Nanocomposite Using Pulsed Laser Ablation for Anticancer Applications

AU - Alheshibri, Muidh

AU - Elsayed, Khaled A.

AU - Khan, Firdos Alam

AU - Haladu, Shamsuddeen A.

AU - Ercan, Filiz

AU - Çevik, Emre

AU - Drmosh, Q. A.

AU - Kayed, T. S.

AU - Almessiere, M. A.

PY - 2024/1

Y1 - 2024/1

N2 - Developing a nanosized platform for annihilating cancer cells is highly promising and desirable in the field of nanomedicine especially when an eco-friendly synthesis protocol such as laser ablation is employed. Herein, pulsed laser ablation technique was used to fabricate Au/ZnO nanocomposite in deionized water. The prepared nanostructures were examined using HRTEM, SEM, EDX, XRD, UV–Vis, and Raman spectroscopy. An in vitro cytotoxicity evaluation of the prepared Au/ZnO nanocomposite on human colorectal carcinoma HCT116 and cervical cancer HeLa cells reveals the strong inhibitory action of the nanomaterials on the cancer cells. The influence of the nanocomposites on healthy HEK-293 cell line used as a control was minimal. The outcomes of this work mark the merits of laser ablation in the fabrication of highly pure nanomaterials with good efficacy against cancer cells.

AB - Developing a nanosized platform for annihilating cancer cells is highly promising and desirable in the field of nanomedicine especially when an eco-friendly synthesis protocol such as laser ablation is employed. Herein, pulsed laser ablation technique was used to fabricate Au/ZnO nanocomposite in deionized water. The prepared nanostructures were examined using HRTEM, SEM, EDX, XRD, UV–Vis, and Raman spectroscopy. An in vitro cytotoxicity evaluation of the prepared Au/ZnO nanocomposite on human colorectal carcinoma HCT116 and cervical cancer HeLa cells reveals the strong inhibitory action of the nanomaterials on the cancer cells. The influence of the nanocomposites on healthy HEK-293 cell line used as a control was minimal. The outcomes of this work mark the merits of laser ablation in the fabrication of highly pure nanomaterials with good efficacy against cancer cells.

KW - Anticancer activity

KW - Gold nanoparticles

KW - Laser ablation

KW - Zinc oxide nanoparticles

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JO - Arabian Journal for Science and Engineering

JF - Arabian Journal for Science and Engineering

IS - 1

ER -

Tuning the Morphology of Au/ZnO Nanocomposite Using Pulsed Laser Ablation for Anticancer Applications

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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