Toxicity of nanoscale metal-organic frameworks in biological systems

Muhammad Sajid, Ihsanullah

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Scopus citations


Metal-organic frameworks have demonstrated exciting applications in many research areas including the biomedical sciences due to their unique and tunable structural properties and ultrahigh surface areas. The role of MOFs as drug carriers is a subject of extensive research in this field. However, very little is known about the toxicity of the MOFs in the biological systems. In this chapter, we discussed the role of different factors which may contribute toward the toxicity of the MOFs in biological systems. In addition, few other studies describing the results of in vitro and in vivo toxicities of MOFs are also discussed. Finally, the procedures that may help avoiding occupational exposure to MOFs are highlighted.

Original languageEnglish
Title of host publicationMetal-Organic Frameworks for Biomedical Applications
Number of pages13
ISBN (Electronic)9780128169841
StatePublished - 1 Jan 2020

Bibliographical note

Publisher Copyright:
© 2020 Masoud Mozafari Published by Elsevier Inc.


  • Biological systems
  • Exposure routes
  • Factors affecting MOFs toxicity
  • Metal-organic frameworks
  • Toxicity

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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