TY - GEN
T1 - Towards low-cost, high-sensitivity, integrated biosensors
AU - Deen, M. J.
AU - Shinwari, M. W.
AU - Selvaganapathy, P. R.
PY - 2008
Y1 - 2008
N2 - The early detection of pathogens in a solution sample using a biosensor and associated electronics manufactured in a mainstream semiconductor process is currently attracting much research and development interests around the globe. This is primarily because such a system will be low-cost, easily manufactured, and can offer very high sensitivities, thus potentially stopping the rapid spread of diseases due to water or food contamination. In this paper, we describe our current research on the design and development of an electrolyte-insulator-semiconductor field-effect transistor to detect hybridization of target DNA oligonucleotides using functionalized probes tethered to the insulator's surface of the transistor. This biological sensor, when integrated with associated signal conditioning and processing circuits, promises high sensitivity and cheaper manufacturing costs than current labeled DNA microarray optical sensing systems.
AB - The early detection of pathogens in a solution sample using a biosensor and associated electronics manufactured in a mainstream semiconductor process is currently attracting much research and development interests around the globe. This is primarily because such a system will be low-cost, easily manufactured, and can offer very high sensitivities, thus potentially stopping the rapid spread of diseases due to water or food contamination. In this paper, we describe our current research on the design and development of an electrolyte-insulator-semiconductor field-effect transistor to detect hybridization of target DNA oligonucleotides using functionalized probes tethered to the insulator's surface of the transistor. This biological sensor, when integrated with associated signal conditioning and processing circuits, promises high sensitivity and cheaper manufacturing costs than current labeled DNA microarray optical sensing systems.
KW - BioFET
KW - Biosensors
KW - High-sensitivity sensors
KW - Integrated biosensor
KW - Low-cost biosensors
UR - https://www.scopus.com/pages/publications/51749110019
U2 - 10.1109/ICMEL.2008.4559284
DO - 10.1109/ICMEL.2008.4559284
M3 - Conference contribution
AN - SCOPUS:51749110019
SN - 9781424418824
T3 - "2008 26th International Conference on Microelectronics, Proceedings, MIEL 2008"
SP - 307
EP - 314
BT - 2008 26th International Conference on Microelectronics, Proceedings, MIEL 2008
T2 - 26th International Conference on Microelectronics, MIEL 2008
Y2 - 11 May 2008 through 14 May 2008
ER -
