Tocopherols, polyprenols and steroids from passiflora edulis and bioactivities of its extractives

Md Abdul Aziz; Monira Ahsan; Choudhury Mahmood Hasan; Mohammad Mehedi Masud

doi:10.3329/dujps.v16i1.33382

Tocopherols, polyprenols and steroids from passiflora edulis and bioactivities of its extractives

Md Abdul Aziz, Monira Ahsan, Choudhury Mahmood Hasan, Mohammad Mehedi Masud^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

β-tocopherol (1), δ-tocopherol (2), polyprenol-12 (3), polyprenol-15 (4), stigmasterol and β-sitosterol were isolated from the yellow flavicarpa variety of leaves of Passiflora edulis. The structures of the isolated compounds were elucidated using¹H-NR and¹³C-NMR spectral analysis. The organic and aqueous soluble fractions of crude methanolic extract were evaluated for the antioxidant, cytotoxic, thrombolytic and antimicrobial activities. In DPPH free radical scavenging assay, the aqueous soluble fraction displayed maximum activity having IC₅₀ value of 139.56µg/ml. On the other hand, dichloromethane soluble fraction revealed maximum cytotoxic (LC₅₀ 24.17µg/ml) and thrombolytic (14.49% clot lysis) activities, when compared to the respective blanks.

Original language	English
Pages (from-to)	55-60
Number of pages	6
Journal	Dhaka University Journal of Pharmaceutical Sciences
Volume	16
Issue number	1
DOIs	https://doi.org/10.3329/dujps.v16i1.33382
State	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017, University of Dhaka. All rights reserved.

Keywords

Antioxidant
Chromatography
DPPH
Passiflora edulis
Polyprenol
Thrombolysis
Tocopherol

ASJC Scopus subject areas

Pharmaceutical Science
Pharmacology (medical)

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10.3329/dujps.v16i1.33382

Cite this

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title = "Tocopherols, polyprenols and steroids from passiflora edulis and bioactivities of its extractives",

abstract = "β-tocopherol (1), δ-tocopherol (2), polyprenol-12 (3), polyprenol-15 (4), stigmasterol and β-sitosterol were isolated from the yellow flavicarpa variety of leaves of Passiflora edulis. The structures of the isolated compounds were elucidated using1H-NR and13C-NMR spectral analysis. The organic and aqueous soluble fractions of crude methanolic extract were evaluated for the antioxidant, cytotoxic, thrombolytic and antimicrobial activities. In DPPH free radical scavenging assay, the aqueous soluble fraction displayed maximum activity having IC50 value of 139.56µg/ml. On the other hand, dichloromethane soluble fraction revealed maximum cytotoxic (LC50 24.17µg/ml) and thrombolytic (14.49\% clot lysis) activities, when compared to the respective blanks.",

keywords = "Antioxidant, Chromatography, DPPH, Passiflora edulis, Polyprenol, Thrombolysis, Tocopherol",

author = "Aziz, \{Md Abdul\} and Monira Ahsan and Hasan, \{Choudhury Mahmood\} and Masud, \{Mohammad Mehedi\}",

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doi = "10.3329/dujps.v16i1.33382",

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pages = "55--60",

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TY - JOUR

T1 - Tocopherols, polyprenols and steroids from passiflora edulis and bioactivities of its extractives

AU - Aziz, Md Abdul

AU - Ahsan, Monira

AU - Hasan, Choudhury Mahmood

AU - Masud, Mohammad Mehedi

PY - 2017

Y1 - 2017

N2 - β-tocopherol (1), δ-tocopherol (2), polyprenol-12 (3), polyprenol-15 (4), stigmasterol and β-sitosterol were isolated from the yellow flavicarpa variety of leaves of Passiflora edulis. The structures of the isolated compounds were elucidated using1H-NR and13C-NMR spectral analysis. The organic and aqueous soluble fractions of crude methanolic extract were evaluated for the antioxidant, cytotoxic, thrombolytic and antimicrobial activities. In DPPH free radical scavenging assay, the aqueous soluble fraction displayed maximum activity having IC50 value of 139.56µg/ml. On the other hand, dichloromethane soluble fraction revealed maximum cytotoxic (LC50 24.17µg/ml) and thrombolytic (14.49% clot lysis) activities, when compared to the respective blanks.

AB - β-tocopherol (1), δ-tocopherol (2), polyprenol-12 (3), polyprenol-15 (4), stigmasterol and β-sitosterol were isolated from the yellow flavicarpa variety of leaves of Passiflora edulis. The structures of the isolated compounds were elucidated using1H-NR and13C-NMR spectral analysis. The organic and aqueous soluble fractions of crude methanolic extract were evaluated for the antioxidant, cytotoxic, thrombolytic and antimicrobial activities. In DPPH free radical scavenging assay, the aqueous soluble fraction displayed maximum activity having IC50 value of 139.56µg/ml. On the other hand, dichloromethane soluble fraction revealed maximum cytotoxic (LC50 24.17µg/ml) and thrombolytic (14.49% clot lysis) activities, when compared to the respective blanks.

KW - Antioxidant

KW - Chromatography

KW - DPPH

KW - Passiflora edulis

KW - Polyprenol

KW - Thrombolysis

KW - Tocopherol

UR - https://www.scopus.com/pages/publications/85026676068

U2 - 10.3329/dujps.v16i1.33382

DO - 10.3329/dujps.v16i1.33382

M3 - Article

AN - SCOPUS:85026676068

SN - 1816-1820

VL - 16

SP - 55

EP - 60

JO - Dhaka University Journal of Pharmaceutical Sciences

JF - Dhaka University Journal of Pharmaceutical Sciences

IS - 1

ER -

Tocopherols, polyprenols and steroids from passiflora edulis and bioactivities of its extractives

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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