Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing

Aasif Helal; Sang Hyun Kim; Hong Seok Kim

doi:10.1016/j.tet.2010.10.055

Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing

Aasif Helal, Sang Hyun Kim, Hong Seok Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

A new thiazole sulfonamide (TTP, 1) based Zn²⁺ selective intrinsic chemosensor has been synthesized and investigated. The chemosensor shows a selective fluorescence enhancement (3.0 fold) with Zn²⁺ over biologically relevant cations (Ca²⁺, Mg²⁺, Na⁺, and K⁺) and biologically non-relevant cations (Cd²⁺) in an aqueous ethanol system. It produces an increase in the quantum yield and a longer emission wavelength shift (64 nm) on Zn²⁺ binding with the potential of a ratiometric assay.

Original language	English
Pages (from-to)	9925-9932
Number of pages	8
Journal	Tetrahedron
Volume	66
Issue number	52
DOIs	https://doi.org/10.1016/j.tet.2010.10.055
State	Published - 24 Dec 2010
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), and funded by the Ministry of Education, Science and Technology ( 20100010070 ). A.H. was also supported by the Research Institute of Industrial Technology at Kyungpook National University.

Keywords

Chemosensor
ESIPT
Fluorescence
Ratiometric sensing of Zn
Thiazole sulfonamide

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2010.10.055

Cite this

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title = "Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing",

abstract = "A new thiazole sulfonamide (TTP, 1) based Zn2+ selective intrinsic chemosensor has been synthesized and investigated. The chemosensor shows a selective fluorescence enhancement (3.0 fold) with Zn2+ over biologically relevant cations (Ca2+, Mg2+, Na+, and K+) and biologically non-relevant cations (Cd2+) in an aqueous ethanol system. It produces an increase in the quantum yield and a longer emission wavelength shift (64 nm) on Zn2+ binding with the potential of a ratiometric assay.",

keywords = "Chemosensor, ESIPT, Fluorescence, Ratiometric sensing of Zn, Thiazole sulfonamide",

author = "Aasif Helal and Kim, \{Sang Hyun\} and Kim, \{Hong Seok\}",

note = "Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), and funded by the Ministry of Education, Science and Technology ( 20100010070 ). A.H. was also supported by the Research Institute of Industrial Technology at Kyungpook National University. ",

year = "2010",

month = dec,

day = "24",

doi = "10.1016/j.tet.2010.10.055",

language = "English",

volume = "66",

pages = "9925--9932",

journal = "Tetrahedron",

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T1 - Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing

AU - Helal, Aasif

AU - Kim, Sang Hyun

AU - Kim, Hong Seok

N1 - Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), and funded by the Ministry of Education, Science and Technology ( 20100010070 ). A.H. was also supported by the Research Institute of Industrial Technology at Kyungpook National University.

PY - 2010/12/24

Y1 - 2010/12/24

N2 - A new thiazole sulfonamide (TTP, 1) based Zn2+ selective intrinsic chemosensor has been synthesized and investigated. The chemosensor shows a selective fluorescence enhancement (3.0 fold) with Zn2+ over biologically relevant cations (Ca2+, Mg2+, Na+, and K+) and biologically non-relevant cations (Cd2+) in an aqueous ethanol system. It produces an increase in the quantum yield and a longer emission wavelength shift (64 nm) on Zn2+ binding with the potential of a ratiometric assay.

AB - A new thiazole sulfonamide (TTP, 1) based Zn2+ selective intrinsic chemosensor has been synthesized and investigated. The chemosensor shows a selective fluorescence enhancement (3.0 fold) with Zn2+ over biologically relevant cations (Ca2+, Mg2+, Na+, and K+) and biologically non-relevant cations (Cd2+) in an aqueous ethanol system. It produces an increase in the quantum yield and a longer emission wavelength shift (64 nm) on Zn2+ binding with the potential of a ratiometric assay.

KW - Chemosensor

KW - ESIPT

KW - Fluorescence

KW - Ratiometric sensing of Zn

KW - Thiazole sulfonamide

UR - https://www.scopus.com/pages/publications/78649642438

U2 - 10.1016/j.tet.2010.10.055

DO - 10.1016/j.tet.2010.10.055

M3 - Article

AN - SCOPUS:78649642438

SN - 0040-4020

VL - 66

SP - 9925

EP - 9932

JO - Tetrahedron

JF - Tetrahedron

IS - 52

ER -

Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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