Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

Alexis M. Nzila; Gilbert Kokwaro; Peter A. Winstanley; Kevin Marsh; Steve A. Ward

doi:10.1016/j.pt.2003.12.005

Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

Alexis M. Nzila^*
, Gilbert Kokwaro
, Peter A. Winstanley
, Kevin Marsh
, Steve A. Ward

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

17 Scopus citations

Abstract

Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

Original language	English
Pages (from-to)	109-112
Number of pages	4
Journal	Trends in Parasitology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.pt.2003.12.005
State	Published - Mar 2004
Externally published	Yes

Bibliographical note

Funding Information:
We thank the director of Kenya Medical Research Institute for permission to publish these data. This work was supported by the Wellcome Trust (no. 056769). A.N. and K.M. are grateful to the Wellcome Trust for personal support. P.W. and S.A.W. are grateful to the Wellcome Trust for institutional support.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Parasitology
Infectious Diseases

Access to Document

10.1016/j.pt.2003.12.005

Cite this

@article{989bbe9024c441a4b62081752fa861eb,

title = "Therapeutic potential of folate uptake inhibition in Plasmodium falciparum",

abstract = "Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.",

author = "Nzila, \{Alexis M.\} and Gilbert Kokwaro and Winstanley, \{Peter A.\} and Kevin Marsh and Ward, \{Steve A.\}",

note = "Funding Information: We thank the director of Kenya Medical Research Institute for permission to publish these data. This work was supported by the Wellcome Trust (no. 056769). A.N. and K.M. are grateful to the Wellcome Trust for personal support. P.W. and S.A.W. are grateful to the Wellcome Trust for institutional support.",

year = "2004",

month = mar,

doi = "10.1016/j.pt.2003.12.005",

language = "English",

volume = "20",

pages = "109--112",

number = "3",

}

TY - JOUR

T1 - Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

AU - Nzila, Alexis M.

AU - Kokwaro, Gilbert

AU - Winstanley, Peter A.

AU - Marsh, Kevin

AU - Ward, Steve A.

N1 - Funding Information: We thank the director of Kenya Medical Research Institute for permission to publish these data. This work was supported by the Wellcome Trust (no. 056769). A.N. and K.M. are grateful to the Wellcome Trust for personal support. P.W. and S.A.W. are grateful to the Wellcome Trust for institutional support.

PY - 2004/3

Y1 - 2004/3

N2 - Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

AB - Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

UR - https://www.scopus.com/pages/publications/1342328135

U2 - 10.1016/j.pt.2003.12.005

DO - 10.1016/j.pt.2003.12.005

M3 - Short survey

C2 - 16676416

AN - SCOPUS:1342328135

SN - 1471-4922

VL - 20

SP - 109

EP - 112

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 3

ER -

Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

Abstract

Bibliographical note

UN SDGs

ASJC Scopus subject areas

Access to Document

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