Abstract
The oxa-Michael reaction (OMR) offers the most effective and straightforward route to the synthesis of a wide range of 5- A nd 6-membered oxygen-containing heterocycles including tetrahydropyrans, tetrahydrofurans, 1,4 dioxanes, isoxazolidines, isoxazolines, γ-lactones and related γ-butenolides. These molecular frameworks are frequently featured in numerous biologically active substances. Moreover, the emergence of organocatalytic asymmetric OMR has empowered access to a variety of diverse oxygen-containing heterocycles in a highly enantio- A nd/or diastereoselective fashion. This review provides an updated account on the recent advances and applications of OMR in the synthesis 5- A nd 6-membered monocyclic oxo-heterocycles published in the literature since 2013 to date.
| Original language | English |
|---|---|
| Pages (from-to) | 1329-1344 |
| Number of pages | 16 |
| Journal | Organic Chemistry Frontiers |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| State | Published - 21 Mar 2021 |
Bibliographical note
Publisher Copyright:© the Partner Organisations.
ASJC Scopus subject areas
- Organic Chemistry