The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase

Nisar Ullah; Khaled M. Arafeh

doi:10.1016/j.tetlet.2008.10.103

The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase

Nisar Ullah^*, Khaled M. Arafeh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase (Icmt), was accomplished in an overall high yielding reaction sequence.

Original language	English
Pages (from-to)	158-160
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	2
DOIs	https://doi.org/10.1016/j.tetlet.2008.10.103
State	Published - 14 Jan 2009

Keywords

Anticancer drug
Aplysamine 6
Chemoselective acylation
Icmt inhibitor

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2008.10.103

Cite this

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title = "The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase",

abstract = "The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase (Icmt), was accomplished in an overall high yielding reaction sequence.",

keywords = "Anticancer drug, Aplysamine 6, Chemoselective acylation, Icmt inhibitor",

author = "Nisar Ullah and Arafeh, \{Khaled M.\}",

year = "2009",

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pages = "158--160",

journal = "Tetrahedron Letters",

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T1 - The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase

AU - Ullah, Nisar

AU - Arafeh, Khaled M.

PY - 2009/1/14

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N2 - The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase (Icmt), was accomplished in an overall high yielding reaction sequence.

AB - The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase (Icmt), was accomplished in an overall high yielding reaction sequence.

KW - Anticancer drug

KW - Aplysamine 6

KW - Chemoselective acylation

KW - Icmt inhibitor

UR - https://www.scopus.com/pages/publications/56949098267

U2 - 10.1016/j.tetlet.2008.10.103

DO - 10.1016/j.tetlet.2008.10.103

M3 - Article

AN - SCOPUS:56949098267

SN - 0040-4039

VL - 50

SP - 158

EP - 160

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 2

ER -

The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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