Tetrakis(thione)platinum(II) complexes: Synthesis, spectroscopic characterization, crystal structures, and in vitro cytotoxicity

A. Zainelabdeen A. Mustafa; M. Monim-ul-Mehboob; M. Y. Jomaa; M. Altaf; M. Fettouhi; A. A. Isab; M. I.M. Wazeer; H. Stoeckli-Evans; G. Bhatia; V. Dhuna

doi:10.1080/00958972.2015.1072175

Tetrakis(thione)platinum(II) complexes: Synthesis, spectroscopic characterization, crystal structures, and in vitro cytotoxicity

A. Zainelabdeen A. Mustafa, M. Monim-ul-Mehboob, M. Y. Jomaa, M. Altaf, M. Fettouhi, A. A. Isab^*, M. I.M. Wazeer, H. Stoeckli-Evans, G. Bhatia, V. Dhuna

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A new series of platinum(II) complexes based on thione ligands with general formula [Pt(thione)₄]X₂ (X^- = Cl^-, NO₃^-) has been synthesized and characterized using CHNS elemental analysis, infrared, ¹H and ¹³C solution-state NMR as well as ¹³C and ¹⁵N solid-state NMR spectroscopy, and X-ray crystallography. The spectroscopic methods confirm the coordination of Pt(II) with thiocarbonyl groups via sulfur of the thione ligands. The X-ray structures showed a distorted square planar geometry for 1, [Pt(MeImt)₄]Cl₂ (MeImt = N-Methylimidazolidine-2-thione) while the hydrogen bonding interactions in 7, [Pt(iPrImt)₄](NO₃)₂·0.6(H₂O) induce a bent see-saw distortion relative to the ideal square planar geometry. The in vitro cytotoxicity studies showed that 2, [Pt(EtImt)₄]Cl₂ is generally the most effective, a two-fold better cytotoxic agent than cisplatin and carboplatin against MCF7 (human breast cancer).

Original language	English
Pages (from-to)	3511-3524
Number of pages	14
Journal	Journal of Coordination Chemistry
Volume	68
Issue number	19
DOIs	https://doi.org/10.1080/00958972.2015.1072175
State	Published - 2 Oct 2015

Bibliographical note

Publisher Copyright:
© 2015 © 2015 Taylor & Francis.

Keywords

1 3-Diazipane-2-thione
In vitro cytotoxicity
N-Alkylimidazolidine-2-thione
N-Ethyl-1 3-diazinane-2-thione
NMR
Pt(II) thione complexes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/00958972.2015.1072175

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Mustafa, A. Z. A., Monim-ul-Mehboob, M., Jomaa, M. Y., Altaf, M., Fettouhi, M., Isab, A. A., Wazeer, M. I. M., Stoeckli-Evans, H., Bhatia, G., & Dhuna, V. (2015). Tetrakis(thione)platinum(II) complexes: Synthesis, spectroscopic characterization, crystal structures, and in vitro cytotoxicity. Journal of Coordination Chemistry, 68(19), 3511-3524. https://doi.org/10.1080/00958972.2015.1072175

@article{6026585c84bf4f41958e4b4623245d64,

title = "Tetrakis(thione)platinum(II) complexes: Synthesis, spectroscopic characterization, crystal structures, and in vitro cytotoxicity",

abstract = "A new series of platinum(II) complexes based on thione ligands with general formula [Pt(thione)4]X2 (X- = Cl-, NO3-) has been synthesized and characterized using CHNS elemental analysis, infrared, 1H and 13C solution-state NMR as well as 13C and 15N solid-state NMR spectroscopy, and X-ray crystallography. The spectroscopic methods confirm the coordination of Pt(II) with thiocarbonyl groups via sulfur of the thione ligands. The X-ray structures showed a distorted square planar geometry for 1, [Pt(MeImt)4]Cl2 (MeImt = N-Methylimidazolidine-2-thione) while the hydrogen bonding interactions in 7, [Pt(iPrImt)4](NO3)2·0.6(H2O) induce a bent see-saw distortion relative to the ideal square planar geometry. The in vitro cytotoxicity studies showed that 2, [Pt(EtImt)4]Cl2 is generally the most effective, a two-fold better cytotoxic agent than cisplatin and carboplatin against MCF7 (human breast cancer).",

keywords = "1 3-Diazipane-2-thione, In vitro cytotoxicity, N-Alkylimidazolidine-2-thione, N-Ethyl-1 3-diazinane-2-thione, NMR, Pt(II) thione complexes",

author = "Mustafa, \{A. Zainelabdeen A.\} and M. Monim-ul-Mehboob and Jomaa, \{M. Y.\} and M. Altaf and M. Fettouhi and Isab, \{A. A.\} and Wazeer, \{M. I.M.\} and H. Stoeckli-Evans and G. Bhatia and V. Dhuna",

note = "Publisher Copyright: {\textcopyright} 2015 {\textcopyright} 2015 Taylor \& Francis.",

year = "2015",

month = oct,

day = "2",

doi = "10.1080/00958972.2015.1072175",

language = "English",

volume = "68",

pages = "3511--3524",

journal = "Journal of Coordination Chemistry",

issn = "0095-8972",

number = "19",

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Mustafa, AZA, Monim-ul-Mehboob, M, Jomaa, MY, Altaf, M, Fettouhi, M, Isab, AA, Wazeer, MIM, Stoeckli-Evans, H, Bhatia, G & Dhuna, V 2015, 'Tetrakis(thione)platinum(II) complexes: Synthesis, spectroscopic characterization, crystal structures, and in vitro cytotoxicity', Journal of Coordination Chemistry, vol. 68, no. 19, pp. 3511-3524. https://doi.org/10.1080/00958972.2015.1072175

TY - JOUR

T1 - Tetrakis(thione)platinum(II) complexes

T2 - Synthesis, spectroscopic characterization, crystal structures, and in vitro cytotoxicity

AU - Mustafa, A. Zainelabdeen A.

AU - Monim-ul-Mehboob, M.

AU - Jomaa, M. Y.

AU - Altaf, M.

AU - Fettouhi, M.

AU - Isab, A. A.

AU - Wazeer, M. I.M.

AU - Stoeckli-Evans, H.

AU - Bhatia, G.

AU - Dhuna, V.

PY - 2015/10/2

Y1 - 2015/10/2

N2 - A new series of platinum(II) complexes based on thione ligands with general formula [Pt(thione)4]X2 (X- = Cl-, NO3-) has been synthesized and characterized using CHNS elemental analysis, infrared, 1H and 13C solution-state NMR as well as 13C and 15N solid-state NMR spectroscopy, and X-ray crystallography. The spectroscopic methods confirm the coordination of Pt(II) with thiocarbonyl groups via sulfur of the thione ligands. The X-ray structures showed a distorted square planar geometry for 1, [Pt(MeImt)4]Cl2 (MeImt = N-Methylimidazolidine-2-thione) while the hydrogen bonding interactions in 7, [Pt(iPrImt)4](NO3)2·0.6(H2O) induce a bent see-saw distortion relative to the ideal square planar geometry. The in vitro cytotoxicity studies showed that 2, [Pt(EtImt)4]Cl2 is generally the most effective, a two-fold better cytotoxic agent than cisplatin and carboplatin against MCF7 (human breast cancer).

AB - A new series of platinum(II) complexes based on thione ligands with general formula [Pt(thione)4]X2 (X- = Cl-, NO3-) has been synthesized and characterized using CHNS elemental analysis, infrared, 1H and 13C solution-state NMR as well as 13C and 15N solid-state NMR spectroscopy, and X-ray crystallography. The spectroscopic methods confirm the coordination of Pt(II) with thiocarbonyl groups via sulfur of the thione ligands. The X-ray structures showed a distorted square planar geometry for 1, [Pt(MeImt)4]Cl2 (MeImt = N-Methylimidazolidine-2-thione) while the hydrogen bonding interactions in 7, [Pt(iPrImt)4](NO3)2·0.6(H2O) induce a bent see-saw distortion relative to the ideal square planar geometry. The in vitro cytotoxicity studies showed that 2, [Pt(EtImt)4]Cl2 is generally the most effective, a two-fold better cytotoxic agent than cisplatin and carboplatin against MCF7 (human breast cancer).

KW - 1 3-Diazipane-2-thione

KW - In vitro cytotoxicity

KW - N-Alkylimidazolidine-2-thione

KW - N-Ethyl-1 3-diazinane-2-thione

KW - NMR

KW - Pt(II) thione complexes

UR - https://www.scopus.com/pages/publications/84941742365

U2 - 10.1080/00958972.2015.1072175

DO - 10.1080/00958972.2015.1072175

M3 - Article

AN - SCOPUS:84941742365

SN - 0095-8972

VL - 68

SP - 3511

EP - 3524

JO - Journal of Coordination Chemistry

JF - Journal of Coordination Chemistry

IS - 19

ER -

Tetrakis(thione)platinum(II) complexes: Synthesis, spectroscopic characterization, crystal structures, and in vitro cytotoxicity

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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