Temperature-sensitive polymers for drug delivery

Scott D. Fitzpatrick; Lindsay E. Fitzpatrick; Ajit Thakur; Mohammad A.Jafar Mazumder; Heather Sheardown

doi:10.1586/erd.12.24

Temperature-sensitive polymers for drug delivery

Scott D. Fitzpatrick, Lindsay E. Fitzpatrick, Ajit Thakur, Mohammad A.Jafar Mazumder, Heather Sheardown^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The ability to undergo rapid changes in response to subtle environmental cues make stimuli- responsive materials attractive candidates for minimally invasive, targeted and personalized drug delivery applications. This special report aims to highlight and provide a brief description of several of the significant natural and synthetic temperature-responsive materials that have clinical relevance for drug delivery applications. This report examines the advantages and disadvantages of natural versus synthetic materials and outlines various scaffold architectures that can be utilized with temperature-sensitive drug delivery materials. The authors provide a commentary on the current state of the field and provide their insight into future expectations for temperature-sensitive drug delivery, emphasizing the importance of the emergence of dual and multiresponsive systems capable of responding precisely to an expanding set of stimuli, thereby allowing the development of disease-specific drug delivery vehicles.

Original language	English
Pages (from-to)	339-351
Number of pages	13
Journal	Expert Review of Medical Devices
Volume	9
Issue number	4
DOIs	https://doi.org/10.1586/erd.12.24
State	Published - Jul 2012

Bibliographical note

Funding Information:
The authors would like to acknowledge NSERC and the NSERC 20/20 Ophthalmic Materials Network for funding. H Sheardown is the founder of the 20/20 NSERC Ophthalmic Materials Network, which had/has ties with and receives funding from the following industrial partners: Alimera Sciences, CIBA Vision Corporation, Custom Contact Lenses, GlaxoSmithKline, Fovea Pharmaceuticals, iCo Therapeutics, Siltech Corporation, Take Control Cosmedix, Vista Optics Limited and Walsh Medical Devices Incorporated. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Keywords

N-isopropylacrylamide
drug delivery
intelligent polymers
lower critical solution temperature
smart polymers
sustained release
targeted
temperature-sensitive
thermoresponsive

ASJC Scopus subject areas

Surgery
Biomedical Engineering

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10.1586/erd.12.24

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abstract = "The ability to undergo rapid changes in response to subtle environmental cues make stimuli- responsive materials attractive candidates for minimally invasive, targeted and personalized drug delivery applications. This special report aims to highlight and provide a brief description of several of the significant natural and synthetic temperature-responsive materials that have clinical relevance for drug delivery applications. This report examines the advantages and disadvantages of natural versus synthetic materials and outlines various scaffold architectures that can be utilized with temperature-sensitive drug delivery materials. The authors provide a commentary on the current state of the field and provide their insight into future expectations for temperature-sensitive drug delivery, emphasizing the importance of the emergence of dual and multiresponsive systems capable of responding precisely to an expanding set of stimuli, thereby allowing the development of disease-specific drug delivery vehicles.",

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Temperature-sensitive polymers for drug delivery

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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