Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury

Tiziano M. Scarabelli; Sofia Mariotto; Safwat Abdel-Azeim; Kazuo Shoji; Elena Darra; Anastasis Stephanou; Carol Chen-Scarabelli; Jean Didier Marechal; Richard Knight; Anna Ciampa; Louis Saravolatz; Alessandra Carcereri de Prati; Zhaokan Yuan; Elisabetta Cavalieri; Marta Menegazzi; David Latchman; Cosimo Pizza; David Perahia; Hisanori Suzuki

doi:10.1016/j.febslet.2008.12.037

Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury

Tiziano M. Scarabelli
, Sofia Mariotto^*
, Safwat Abdel-Azeim
, Kazuo Shoji
, Elena Darra
, Anastasis Stephanou
, Carol Chen-Scarabelli
, Jean Didier Marechal
, Richard Knight
, Anna Ciampa
, Louis Saravolatz
, Alessandra Carcereri de Prati
, Zhaokan Yuan
, Elisabetta Cavalieri
, Marta Menegazzi
, David Latchman
, Cosimo Pizza
, David Perahia
, Hisanori Suzuki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Flavonoids exhibit a variety of beneficial effects in cardiovascular diseases. Although their therapeutic properties have been attributed mainly to their antioxidant action, they have additional protective mechanisms such as inhibition of signal transducer and activator of transcription 1 (STAT1) activation. Here, we have investigated the cardioprotective mechanisms of strong antioxidant flavonoids such as quercetin, myricetin and delphinidin. Although all of them protect the heart from ischemia/reperfusion-injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation. Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity.

Original language	English
Pages (from-to)	531-541
Number of pages	11
Journal	FEBS Letters
Volume	583
Issue number	3
DOIs	https://doi.org/10.1016/j.febslet.2008.12.037
State	Published - 4 Feb 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antioxidant flavonoid
Apoptosis
Heart ischemia/reperfusion
STAT1
Surface plasmon resonance

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2008.12.037

Cite this

Scarabelli, T. M., Mariotto, S., Abdel-Azeim, S., Shoji, K., Darra, E., Stephanou, A., Chen-Scarabelli, C., Marechal, J. D., Knight, R., Ciampa, A., Saravolatz, L., de Prati, A. C., Yuan, Z., Cavalieri, E., Menegazzi, M., Latchman, D., Pizza, C., Perahia, D., & Suzuki, H. (2009). Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury. FEBS Letters, 583(3), 531-541. https://doi.org/10.1016/j.febslet.2008.12.037

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abstract = "Flavonoids exhibit a variety of beneficial effects in cardiovascular diseases. Although their therapeutic properties have been attributed mainly to their antioxidant action, they have additional protective mechanisms such as inhibition of signal transducer and activator of transcription 1 (STAT1) activation. Here, we have investigated the cardioprotective mechanisms of strong antioxidant flavonoids such as quercetin, myricetin and delphinidin. Although all of them protect the heart from ischemia/reperfusion-injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation. Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity.",

keywords = "Antioxidant flavonoid, Apoptosis, Heart ischemia/reperfusion, STAT1, Surface plasmon resonance",

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Scarabelli, TM, Mariotto, S, Abdel-Azeim, S, Shoji, K, Darra, E, Stephanou, A, Chen-Scarabelli, C, Marechal, JD, Knight, R, Ciampa, A, Saravolatz, L, de Prati, AC, Yuan, Z, Cavalieri, E, Menegazzi, M, Latchman, D, Pizza, C, Perahia, D & Suzuki, H 2009, 'Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury', FEBS Letters, vol. 583, no. 3, pp. 531-541. https://doi.org/10.1016/j.febslet.2008.12.037

TY - JOUR

T1 - Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury

AU - Scarabelli, Tiziano M.

AU - Mariotto, Sofia

AU - Abdel-Azeim, Safwat

AU - Shoji, Kazuo

AU - Darra, Elena

AU - Stephanou, Anastasis

AU - Chen-Scarabelli, Carol

AU - Marechal, Jean Didier

AU - Knight, Richard

AU - Ciampa, Anna

AU - Saravolatz, Louis

AU - de Prati, Alessandra Carcereri

AU - Yuan, Zhaokan

AU - Cavalieri, Elisabetta

AU - Menegazzi, Marta

AU - Latchman, David

AU - Pizza, Cosimo

AU - Perahia, David

AU - Suzuki, Hisanori

PY - 2009/2/4

Y1 - 2009/2/4

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AB - Flavonoids exhibit a variety of beneficial effects in cardiovascular diseases. Although their therapeutic properties have been attributed mainly to their antioxidant action, they have additional protective mechanisms such as inhibition of signal transducer and activator of transcription 1 (STAT1) activation. Here, we have investigated the cardioprotective mechanisms of strong antioxidant flavonoids such as quercetin, myricetin and delphinidin. Although all of them protect the heart from ischemia/reperfusion-injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation. Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity.

KW - Antioxidant flavonoid

KW - Apoptosis

KW - Heart ischemia/reperfusion

KW - STAT1

KW - Surface plasmon resonance

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SN - 0014-5793

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SP - 531

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JO - FEBS Letters

JF - FEBS Letters

IS - 3

ER -

Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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