Tackling the problem of antimalarial resistance

John Okombo; Leah Mwai; Alexis Nzila

doi:10.1007/978-3-642-28175-4_13

Tackling the problem of antimalarial resistance

John Okombo
, Leah Mwai
, Alexis Nzila^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The emergence and spread of resistance remain a burgeoning problem in the control and the management of malaria. Effort has been dedicated in discovering and developing new drugs; however, these efforts are hampered by the rapid selection of resistance. For instance, there is no single antimalarial in clinical use against which the parasite has not yet developed resistance. To counterbalance this rapid development of resistance, not only should new drugs be developed, but the mechanisms of resistance to existing drugs need to be fully understood. Indeed, understanding these mechanisms could lead to identifying simple ways, by the use of single markers, to map and monitor the emergence and spread of drug resistance. In addition, such studies could also contribute to clarifying the mode of action drug, which eventually could lead to the discovery of new targets and thus new drugs. In this chapter, we have reviewed our current knowledge and presented existing challenges and gaps, on the mechanisms of resistance to most clinically important antimalarials.

Original language	English
Title of host publication	Drug Discovery in Africa
Subtitle of host publication	Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs
Publisher	Springer-Verlag Berlin Heidelberg
Pages	301-324
Number of pages	24
Volume	9783642281754
ISBN (Electronic)	9783642281754
ISBN (Print)	3642281745, 9783642281747
DOIs	https://doi.org/10.1007/978-3-642-28175-4_13
State	Published - 1 Aug 2013
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2012 Springer-Verlag Berlin Heidelberg. All rights are reserved.

ASJC Scopus subject areas

General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-642-28175-4_13

Cite this

Okombo, J., Mwai, L., & Nzila, A. (2013). Tackling the problem of antimalarial resistance. In Drug Discovery in Africa: Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs (Vol. 9783642281754, pp. 301-324). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-28175-4_13

@inbook{80bf7d9de59a4e46b9569c77cc86aff6,

title = "Tackling the problem of antimalarial resistance",

abstract = "The emergence and spread of resistance remain a burgeoning problem in the control and the management of malaria. Effort has been dedicated in discovering and developing new drugs; however, these efforts are hampered by the rapid selection of resistance. For instance, there is no single antimalarial in clinical use against which the parasite has not yet developed resistance. To counterbalance this rapid development of resistance, not only should new drugs be developed, but the mechanisms of resistance to existing drugs need to be fully understood. Indeed, understanding these mechanisms could lead to identifying simple ways, by the use of single markers, to map and monitor the emergence and spread of drug resistance. In addition, such studies could also contribute to clarifying the mode of action drug, which eventually could lead to the discovery of new targets and thus new drugs. In this chapter, we have reviewed our current knowledge and presented existing challenges and gaps, on the mechanisms of resistance to most clinically important antimalarials.",

author = "John Okombo and Leah Mwai and Alexis Nzila",

note = "Publisher Copyright: {\textcopyright} 2012 Springer-Verlag Berlin Heidelberg. All rights are reserved.",

year = "2013",

month = aug,

day = "1",

doi = "10.1007/978-3-642-28175-4\_13",

language = "English",

isbn = "3642281745",

volume = "9783642281754",

pages = "301--324",

booktitle = "Drug Discovery in Africa",

publisher = "Springer-Verlag Berlin Heidelberg",

}

Okombo, J, Mwai, L & Nzila, A 2013, Tackling the problem of antimalarial resistance. in Drug Discovery in Africa: Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs. vol. 9783642281754, Springer-Verlag Berlin Heidelberg, pp. 301-324. https://doi.org/10.1007/978-3-642-28175-4_13

Tackling the problem of antimalarial resistance. / Okombo, John; Mwai, Leah; Nzila, Alexis.
Drug Discovery in Africa: Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs. Vol. 9783642281754 Springer-Verlag Berlin Heidelberg, 2013. p. 301-324.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Tackling the problem of antimalarial resistance

AU - Okombo, John

AU - Mwai, Leah

AU - Nzila, Alexis

PY - 2013/8/1

Y1 - 2013/8/1

N2 - The emergence and spread of resistance remain a burgeoning problem in the control and the management of malaria. Effort has been dedicated in discovering and developing new drugs; however, these efforts are hampered by the rapid selection of resistance. For instance, there is no single antimalarial in clinical use against which the parasite has not yet developed resistance. To counterbalance this rapid development of resistance, not only should new drugs be developed, but the mechanisms of resistance to existing drugs need to be fully understood. Indeed, understanding these mechanisms could lead to identifying simple ways, by the use of single markers, to map and monitor the emergence and spread of drug resistance. In addition, such studies could also contribute to clarifying the mode of action drug, which eventually could lead to the discovery of new targets and thus new drugs. In this chapter, we have reviewed our current knowledge and presented existing challenges and gaps, on the mechanisms of resistance to most clinically important antimalarials.

AB - The emergence and spread of resistance remain a burgeoning problem in the control and the management of malaria. Effort has been dedicated in discovering and developing new drugs; however, these efforts are hampered by the rapid selection of resistance. For instance, there is no single antimalarial in clinical use against which the parasite has not yet developed resistance. To counterbalance this rapid development of resistance, not only should new drugs be developed, but the mechanisms of resistance to existing drugs need to be fully understood. Indeed, understanding these mechanisms could lead to identifying simple ways, by the use of single markers, to map and monitor the emergence and spread of drug resistance. In addition, such studies could also contribute to clarifying the mode of action drug, which eventually could lead to the discovery of new targets and thus new drugs. In this chapter, we have reviewed our current knowledge and presented existing challenges and gaps, on the mechanisms of resistance to most clinically important antimalarials.

UR - https://www.scopus.com/pages/publications/84929538661

U2 - 10.1007/978-3-642-28175-4_13

DO - 10.1007/978-3-642-28175-4_13

M3 - Chapter

AN - SCOPUS:84929538661

SN - 3642281745

SN - 9783642281747

VL - 9783642281754

SP - 301

EP - 324

BT - Drug Discovery in Africa

PB - Springer-Verlag Berlin Heidelberg

ER -

Tackling the problem of antimalarial resistance

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Fingerprint

Cite this