Synthetic transformations and medicinal significance of 1,2,3-thiadiazoles derivatives: An update

Ali Irfan; Sami Ullah; Ayesha Anum; Nazish Jabeen; Ameer Fawad Zahoor; Hafza Kanwal; Katarzyna Kotwica-Mojzych; Mariusz Mojzych

doi:10.3390/app11125742

Synthetic transformations and medicinal significance of 1,2,3-thiadiazoles derivatives: An update

Ali Irfan
, Sami Ullah
, Ayesha Anum
, Nazish Jabeen
, Ameer Fawad Zahoor^*
, Hafza Kanwal
, Katarzyna Kotwica-Mojzych
, Mariusz Mojzych^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

The 1,2,3-thiadiazole moiety occupies a significant and prominent position among priv-ileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities. The 1,2,3-thiadiazole hybrid structures showed myriad biomedical activities such as antifungal, antiviral, insecticidal, antiamoebic, anticancer and plant acti-vators, etc. In the present review, various synthetic transformations and approaches are highlighted to furnish 1,2,3-thiadiazole scaffolds along with different pharmaceutical and pharmacological activities by virtue of the presence of the 1,2,3-thiadiazole framework on the basis of structure–activity relationship (SAR). The discussion in this review article will attract the attention of synthetic and medicinal researchers to explore 1,2,3-thiadiazole structural motifs for future therapeutic agents.

Original language	English
Article number	5742
Journal	Applied Sciences (Switzerland)
Volume	11
Issue number	12
DOIs	https://doi.org/10.3390/app11125742
State	Published - 2 Jun 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

1,2,3-thiadiazole
Anticancer
Antifun-gal
Antiviral
Biological activities
Insecticidal
Synthetic strategies

ASJC Scopus subject areas

General Materials Science
Instrumentation
General Engineering
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

Access to Document

10.3390/app11125742

Cite this

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title = "Synthetic transformations and medicinal significance of 1,2,3-thiadiazoles derivatives: An update",

abstract = "The 1,2,3-thiadiazole moiety occupies a significant and prominent position among priv-ileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities. The 1,2,3-thiadiazole hybrid structures showed myriad biomedical activities such as antifungal, antiviral, insecticidal, antiamoebic, anticancer and plant acti-vators, etc. In the present review, various synthetic transformations and approaches are highlighted to furnish 1,2,3-thiadiazole scaffolds along with different pharmaceutical and pharmacological activities by virtue of the presence of the 1,2,3-thiadiazole framework on the basis of structure–activity relationship (SAR). The discussion in this review article will attract the attention of synthetic and medicinal researchers to explore 1,2,3-thiadiazole structural motifs for future therapeutic agents.",

keywords = "1,2,3-thiadiazole, Anticancer, Antifun-gal, Antiviral, Biological activities, Insecticidal, Synthetic strategies",

author = "Ali Irfan and Sami Ullah and Ayesha Anum and Nazish Jabeen and Zahoor, \{Ameer Fawad\} and Hafza Kanwal and Katarzyna Kotwica-Mojzych and Mariusz Mojzych",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jun,

day = "2",

doi = "10.3390/app11125742",

language = "English",

volume = "11",

journal = "Applied Sciences (Switzerland)",

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TY - JOUR

T1 - Synthetic transformations and medicinal significance of 1,2,3-thiadiazoles derivatives

T2 - An update

AU - Irfan, Ali

AU - Ullah, Sami

AU - Anum, Ayesha

AU - Jabeen, Nazish

AU - Zahoor, Ameer Fawad

AU - Kanwal, Hafza

AU - Kotwica-Mojzych, Katarzyna

AU - Mojzych, Mariusz

PY - 2021/6/2

Y1 - 2021/6/2

N2 - The 1,2,3-thiadiazole moiety occupies a significant and prominent position among priv-ileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities. The 1,2,3-thiadiazole hybrid structures showed myriad biomedical activities such as antifungal, antiviral, insecticidal, antiamoebic, anticancer and plant acti-vators, etc. In the present review, various synthetic transformations and approaches are highlighted to furnish 1,2,3-thiadiazole scaffolds along with different pharmaceutical and pharmacological activities by virtue of the presence of the 1,2,3-thiadiazole framework on the basis of structure–activity relationship (SAR). The discussion in this review article will attract the attention of synthetic and medicinal researchers to explore 1,2,3-thiadiazole structural motifs for future therapeutic agents.

AB - The 1,2,3-thiadiazole moiety occupies a significant and prominent position among priv-ileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities. The 1,2,3-thiadiazole hybrid structures showed myriad biomedical activities such as antifungal, antiviral, insecticidal, antiamoebic, anticancer and plant acti-vators, etc. In the present review, various synthetic transformations and approaches are highlighted to furnish 1,2,3-thiadiazole scaffolds along with different pharmaceutical and pharmacological activities by virtue of the presence of the 1,2,3-thiadiazole framework on the basis of structure–activity relationship (SAR). The discussion in this review article will attract the attention of synthetic and medicinal researchers to explore 1,2,3-thiadiazole structural motifs for future therapeutic agents.

KW - 1,2,3-thiadiazole

KW - Anticancer

KW - Antifun-gal

KW - Antiviral

KW - Biological activities

KW - Insecticidal

KW - Synthetic strategies

UR - https://www.scopus.com/pages/publications/85109102308

U2 - 10.3390/app11125742

DO - 10.3390/app11125742

M3 - Review article

AN - SCOPUS:85109102308

SN - 2076-3417

VL - 11

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 12

M1 - 5742

ER -

Synthetic transformations and medicinal significance of 1,2,3-thiadiazoles derivatives: An update

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this