Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(III) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines

Said S. Al-Jaroudi; M. Monim-Ul-Mehboob; Muhammad Altaf; Mohammed Fettouhi; Mohammed I.M. Wazeer; Saleh Altuwaijri; Anvarhusein A. Isab

doi:10.1039/c3nj01624b

Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(III) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines

Said S. Al-Jaroudi
, M. Monim-Ul-Mehboob
, Muhammad Altaf
, Mohammed Fettouhi
, Mohammed I.M. Wazeer
, Saleh Altuwaijri
, Anvarhusein A. Isab^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

New gold(III) compounds with chemical formulae [Au{cis-(1,2-DACH)} ₂]Cl₃1, [Au{trans-(±)-(1,2-DACH)} ₂]Cl₃2 and [Au{(S,S)-(+)-1,2-(DACH)}₂]Cl ₃3 (where 1,2-DACH = 1,2-diaminocyclohexane) have been synthesized. The synthesized compounds were characterized using elemental analysis, various spectroscopic techniques including UV-vis, FTIR spectroscopy, solution and solid-state NMR measurements; and X-ray crystallography. The stability of compounds 1, 2 and 3 was checked by UV-vis spectroscopy and NMR measurements. The electrochemical behavior was also investigated through cyclic voltammetry. The potential of the three compounds as anticancer agents was investigated by measuring in vitro cytotoxicity in terms of IC₅₀ and inhibitory effects on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines. [Au{trans-(±)-(1,2-DACH)}₂]Cl₃ (2) showed a better in vitro inhibitory effect on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines than [Au{cis-(1,2-DACH)}₂]Cl₃ (1) and [Au{(S,S)-(+)-(1,2-DACH)}₂]Cl₃ (3).

Original language	English
Pages (from-to)	3199-3211
Number of pages	13
Journal	New Journal of Chemistry
Volume	38
Issue number	7
DOIs	https://doi.org/10.1039/c3nj01624b
State	Published - Jul 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Catalysis
General Chemistry
Materials Chemistry

Access to Document

10.1039/c3nj01624b

Fingerprint

Dive into the research topics of 'Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(III) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines'. Together they form a unique fingerprint.

Cite this

Al-Jaroudi, S. S., Monim-Ul-Mehboob, M., Altaf, M., Fettouhi, M., Wazeer, M. I. M., Altuwaijri, S., & Isab, A. A. (2014). Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(III) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines. New Journal of Chemistry, 38(7), 3199-3211. https://doi.org/10.1039/c3nj01624b

@article{cc037c37a04e4143908d2364ac0955b6,

title = "Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(III) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines",

abstract = "New gold(III) compounds with chemical formulae [Au\{cis-(1,2-DACH)\} 2]Cl31, [Au\{trans-(±)-(1,2-DACH)\} 2]Cl32 and [Au\{(S,S)-(+)-1,2-(DACH)\}2]Cl 33 (where 1,2-DACH = 1,2-diaminocyclohexane) have been synthesized. The synthesized compounds were characterized using elemental analysis, various spectroscopic techniques including UV-vis, FTIR spectroscopy, solution and solid-state NMR measurements; and X-ray crystallography. The stability of compounds 1, 2 and 3 was checked by UV-vis spectroscopy and NMR measurements. The electrochemical behavior was also investigated through cyclic voltammetry. The potential of the three compounds as anticancer agents was investigated by measuring in vitro cytotoxicity in terms of IC50 and inhibitory effects on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines. [Au\{trans-(±)-(1,2-DACH)\}2]Cl3 (2) showed a better in vitro inhibitory effect on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines than [Au\{cis-(1,2-DACH)\}2]Cl3 (1) and [Au\{(S,S)-(+)-(1,2-DACH)\}2]Cl3 (3).",

author = "Al-Jaroudi, \{Said S.\} and M. Monim-Ul-Mehboob and Muhammad Altaf and Mohammed Fettouhi and Wazeer, \{Mohammed I.M.\} and Saleh Altuwaijri and Isab, \{Anvarhusein A.\}",

year = "2014",

month = jul,

doi = "10.1039/c3nj01624b",

language = "English",

volume = "38",

pages = "3199--3211",

journal = "New Journal of Chemistry",

issn = "1144-0546",

publisher = "Royal Society of Chemistry",

number = "7",

}

Al-Jaroudi, SS, Monim-Ul-Mehboob, M, Altaf, M, Fettouhi, M, Wazeer, MIM, Altuwaijri, S & Isab, AA 2014, 'Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(III) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines', New Journal of Chemistry, vol. 38, no. 7, pp. 3199-3211. https://doi.org/10.1039/c3nj01624b

Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(III) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines. / Al-Jaroudi, Said S.; Monim-Ul-Mehboob, M.; Altaf, Muhammad et al.
In: New Journal of Chemistry, Vol. 38, No. 7, 07.2014, p. 3199-3211.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(III) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines

AU - Al-Jaroudi, Said S.

AU - Monim-Ul-Mehboob, M.

AU - Altaf, Muhammad

AU - Fettouhi, Mohammed

AU - Wazeer, Mohammed I.M.

AU - Altuwaijri, Saleh

AU - Isab, Anvarhusein A.

PY - 2014/7

Y1 - 2014/7

N2 - New gold(III) compounds with chemical formulae [Au{cis-(1,2-DACH)} 2]Cl31, [Au{trans-(±)-(1,2-DACH)} 2]Cl32 and [Au{(S,S)-(+)-1,2-(DACH)}2]Cl 33 (where 1,2-DACH = 1,2-diaminocyclohexane) have been synthesized. The synthesized compounds were characterized using elemental analysis, various spectroscopic techniques including UV-vis, FTIR spectroscopy, solution and solid-state NMR measurements; and X-ray crystallography. The stability of compounds 1, 2 and 3 was checked by UV-vis spectroscopy and NMR measurements. The electrochemical behavior was also investigated through cyclic voltammetry. The potential of the three compounds as anticancer agents was investigated by measuring in vitro cytotoxicity in terms of IC50 and inhibitory effects on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines. [Au{trans-(±)-(1,2-DACH)}2]Cl3 (2) showed a better in vitro inhibitory effect on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines than [Au{cis-(1,2-DACH)}2]Cl3 (1) and [Au{(S,S)-(+)-(1,2-DACH)}2]Cl3 (3).

AB - New gold(III) compounds with chemical formulae [Au{cis-(1,2-DACH)} 2]Cl31, [Au{trans-(±)-(1,2-DACH)} 2]Cl32 and [Au{(S,S)-(+)-1,2-(DACH)}2]Cl 33 (where 1,2-DACH = 1,2-diaminocyclohexane) have been synthesized. The synthesized compounds were characterized using elemental analysis, various spectroscopic techniques including UV-vis, FTIR spectroscopy, solution and solid-state NMR measurements; and X-ray crystallography. The stability of compounds 1, 2 and 3 was checked by UV-vis spectroscopy and NMR measurements. The electrochemical behavior was also investigated through cyclic voltammetry. The potential of the three compounds as anticancer agents was investigated by measuring in vitro cytotoxicity in terms of IC50 and inhibitory effects on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines. [Au{trans-(±)-(1,2-DACH)}2]Cl3 (2) showed a better in vitro inhibitory effect on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines than [Au{cis-(1,2-DACH)}2]Cl3 (1) and [Au{(S,S)-(+)-(1,2-DACH)}2]Cl3 (3).

UR - https://www.scopus.com/pages/publications/84902664432

U2 - 10.1039/c3nj01624b

DO - 10.1039/c3nj01624b

M3 - Article

AN - SCOPUS:84902664432

SN - 1144-0546

VL - 38

SP - 3199

EP - 3211

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 7

ER -

Al-Jaroudi SS, Monim-Ul-Mehboob M, Altaf M, Fettouhi M, Wazeer MIM, Altuwaijri S et al. Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(III) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines. New Journal of Chemistry. 2014 Jul;38(7):3199-3211. doi: 10.1039/c3nj01624b