TY - JOUR
T1 - Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(III) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines
AU - Al-Jaroudi, Said S.
AU - Monim-Ul-Mehboob, M.
AU - Altaf, Muhammad
AU - Fettouhi, Mohammed
AU - Wazeer, Mohammed I.M.
AU - Altuwaijri, Saleh
AU - Isab, Anvarhusein A.
PY - 2014/7
Y1 - 2014/7
N2 - New gold(III) compounds with chemical formulae [Au{cis-(1,2-DACH)} 2]Cl31, [Au{trans-(±)-(1,2-DACH)} 2]Cl32 and [Au{(S,S)-(+)-1,2-(DACH)}2]Cl 33 (where 1,2-DACH = 1,2-diaminocyclohexane) have been synthesized. The synthesized compounds were characterized using elemental analysis, various spectroscopic techniques including UV-vis, FTIR spectroscopy, solution and solid-state NMR measurements; and X-ray crystallography. The stability of compounds 1, 2 and 3 was checked by UV-vis spectroscopy and NMR measurements. The electrochemical behavior was also investigated through cyclic voltammetry. The potential of the three compounds as anticancer agents was investigated by measuring in vitro cytotoxicity in terms of IC50 and inhibitory effects on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines. [Au{trans-(±)-(1,2-DACH)}2]Cl3 (2) showed a better in vitro inhibitory effect on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines than [Au{cis-(1,2-DACH)}2]Cl3 (1) and [Au{(S,S)-(+)-(1,2-DACH)}2]Cl3 (3).
AB - New gold(III) compounds with chemical formulae [Au{cis-(1,2-DACH)} 2]Cl31, [Au{trans-(±)-(1,2-DACH)} 2]Cl32 and [Au{(S,S)-(+)-1,2-(DACH)}2]Cl 33 (where 1,2-DACH = 1,2-diaminocyclohexane) have been synthesized. The synthesized compounds were characterized using elemental analysis, various spectroscopic techniques including UV-vis, FTIR spectroscopy, solution and solid-state NMR measurements; and X-ray crystallography. The stability of compounds 1, 2 and 3 was checked by UV-vis spectroscopy and NMR measurements. The electrochemical behavior was also investigated through cyclic voltammetry. The potential of the three compounds as anticancer agents was investigated by measuring in vitro cytotoxicity in terms of IC50 and inhibitory effects on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines. [Au{trans-(±)-(1,2-DACH)}2]Cl3 (2) showed a better in vitro inhibitory effect on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines than [Au{cis-(1,2-DACH)}2]Cl3 (1) and [Au{(S,S)-(+)-(1,2-DACH)}2]Cl3 (3).
UR - http://www.scopus.com/inward/record.url?scp=84902664432&partnerID=8YFLogxK
U2 - 10.1039/c3nj01624b
DO - 10.1039/c3nj01624b
M3 - Article
AN - SCOPUS:84902664432
SN - 1144-0546
VL - 38
SP - 3199
EP - 3211
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 7
ER -
