Synthesis, spectroscopic characterization and in vitro cytotoxic as well as docking studies of cis-diammine platinum(II) complexes of thiones

Mohammed Yagoub Jomaa; Saeed Ahmad; Adam A.A. Seliman; Saheed A. Popoola; Abdul Rajjak Shaikh; Abdulaziz A. Al-Saadi; Gaurav Bhatia; Jatinder Singh; Anvarhusein A. Isab

doi:10.1016/j.ica.2018.09.070

Synthesis, spectroscopic characterization and in vitro cytotoxic as well as docking studies of cis-diammine platinum(II) complexes of thiones

Mohammed Yagoub Jomaa
, Saeed Ahmad
, Adam A.A. Seliman
, Saheed A. Popoola
, Abdul Rajjak Shaikh
, Abdulaziz A. Al-Saadi
, Gaurav Bhatia
, Jatinder Singh
, Anvarhusein A. Isab^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Ten cisplatin-derived platinum(II) complexes of thiones having the general formula, cis-[Pt(NH₃)₂(Thione)₂](NO₃)₂ have been synthesized and characterized by elemental analysis, IR and NMR (¹H & ¹³C) methods. The spectroscopic data is in agreement with the coordination of thiones to platinum(II). The in vitro cytotoxic properties of all these complexes have been investigated against three human cancer cell lines, which include; A549 (lung carcinoma), MCF-7 (breast carcinoma) and HTC15 (colon cancer) and compared to the therapeutically used anticancer agents, cisplatin and carboplatin. The in vitro cytotoxicities in several cases are higher than carboplatin but in all cases are lower than cisplatin. Docking studies are carried out to understand the possible binding mode of interaction of these compounds with DNA.

Original language	English
Pages (from-to)	347-351
Number of pages	5
Journal	Inorganica Chimica Acta
Volume	484
DOIs	https://doi.org/10.1016/j.ica.2018.09.070
State	Published - 1 Jan 2019

Bibliographical note

Publisher Copyright:
© 2018 Elsevier B.V.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer evaluation
Cisplatin
Docking
Heterocyclic thiones
Spectroscopy

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.ica.2018.09.070

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@article{5841952328b544dd9dd9103f1859b83b,

title = "Synthesis, spectroscopic characterization and in vitro cytotoxic as well as docking studies of cis-diammine platinum(II) complexes of thiones",

abstract = "Ten cisplatin-derived platinum(II) complexes of thiones having the general formula, cis-[Pt(NH3)2(Thione)2](NO3)2 have been synthesized and characterized by elemental analysis, IR and NMR (1H \& 13C) methods. The spectroscopic data is in agreement with the coordination of thiones to platinum(II). The in vitro cytotoxic properties of all these complexes have been investigated against three human cancer cell lines, which include; A549 (lung carcinoma), MCF-7 (breast carcinoma) and HTC15 (colon cancer) and compared to the therapeutically used anticancer agents, cisplatin and carboplatin. The in vitro cytotoxicities in several cases are higher than carboplatin but in all cases are lower than cisplatin. Docking studies are carried out to understand the possible binding mode of interaction of these compounds with DNA.",

keywords = "Anticancer evaluation, Cisplatin, Docking, Heterocyclic thiones, Spectroscopy",

author = "Jomaa, \{Mohammed Yagoub\} and Saeed Ahmad and Seliman, \{Adam A.A.\} and Popoola, \{Saheed A.\} and Shaikh, \{Abdul Rajjak\} and Al-Saadi, \{Abdulaziz A.\} and Gaurav Bhatia and Jatinder Singh and Isab, \{Anvarhusein A.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2019",

month = jan,

day = "1",

doi = "10.1016/j.ica.2018.09.070",

language = "English",

volume = "484",

pages = "347--351",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Synthesis, spectroscopic characterization and in vitro cytotoxic as well as docking studies of cis-diammine platinum(II) complexes of thiones

AU - Jomaa, Mohammed Yagoub

AU - Ahmad, Saeed

AU - Seliman, Adam A.A.

AU - Popoola, Saheed A.

AU - Shaikh, Abdul Rajjak

AU - Al-Saadi, Abdulaziz A.

AU - Bhatia, Gaurav

AU - Singh, Jatinder

AU - Isab, Anvarhusein A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Ten cisplatin-derived platinum(II) complexes of thiones having the general formula, cis-[Pt(NH3)2(Thione)2](NO3)2 have been synthesized and characterized by elemental analysis, IR and NMR (1H & 13C) methods. The spectroscopic data is in agreement with the coordination of thiones to platinum(II). The in vitro cytotoxic properties of all these complexes have been investigated against three human cancer cell lines, which include; A549 (lung carcinoma), MCF-7 (breast carcinoma) and HTC15 (colon cancer) and compared to the therapeutically used anticancer agents, cisplatin and carboplatin. The in vitro cytotoxicities in several cases are higher than carboplatin but in all cases are lower than cisplatin. Docking studies are carried out to understand the possible binding mode of interaction of these compounds with DNA.

AB - Ten cisplatin-derived platinum(II) complexes of thiones having the general formula, cis-[Pt(NH3)2(Thione)2](NO3)2 have been synthesized and characterized by elemental analysis, IR and NMR (1H & 13C) methods. The spectroscopic data is in agreement with the coordination of thiones to platinum(II). The in vitro cytotoxic properties of all these complexes have been investigated against three human cancer cell lines, which include; A549 (lung carcinoma), MCF-7 (breast carcinoma) and HTC15 (colon cancer) and compared to the therapeutically used anticancer agents, cisplatin and carboplatin. The in vitro cytotoxicities in several cases are higher than carboplatin but in all cases are lower than cisplatin. Docking studies are carried out to understand the possible binding mode of interaction of these compounds with DNA.

KW - Anticancer evaluation

KW - Cisplatin

KW - Docking

KW - Heterocyclic thiones

KW - Spectroscopy

UR - https://www.scopus.com/pages/publications/85054066877

U2 - 10.1016/j.ica.2018.09.070

DO - 10.1016/j.ica.2018.09.070

M3 - Article

AN - SCOPUS:85054066877

SN - 0020-1693

VL - 484

SP - 347

EP - 351

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

Synthesis, spectroscopic characterization and in vitro cytotoxic as well as docking studies of cis-diammine platinum(II) complexes of thiones

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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