Synthesis, spectroscopic characterization and in vitro anticancer activity of new platinum(II) complexes with some thione ligands in the presence of triethylphosphine

Mohammed Yagoub Jomaa; Muhammed Altaf; Saeed Ahmad; Gaurav Bhatia; Jatinder Singh; Saleh Altuwaijri; Anvarhusein A. Isab

doi:10.1007/s10534-017-0047-5

Synthesis, spectroscopic characterization and in vitro anticancer activity of new platinum(II) complexes with some thione ligands in the presence of triethylphosphine

Mohammed Yagoub Jomaa, Muhammed Altaf, Saeed Ahmad, Gaurav Bhatia, Jatinder Singh, Saleh Altuwaijri, Anvarhusein A. Isab^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Seven new platinum(II) complexes (1–7) of triethylphosphine (Et₃P) and thiones (L) with general formula, cis-[Pt(Et₃P)₂(L)₂]Cl₂ were prepared and characterized by elemental analysis, FTIR and NMR (¹H, ¹³C & ³¹P) measurements. The analytical and spectroscopic data suggested the formation of the desired complexes. The complexes were tested for in vitro cytotoxicity against four cell lines: Hela (human cervical adenocarcinoma), MCF-7 (human breast carcinoma), A549 (human lung carcinoma), and HTC15 (human colon carcinoma). The anticancer activity values of compounds 1–6 are much better than cisplatin and carboplatin as indicated by their IC₅₀ values.

Original language	English
Pages (from-to)	787-795
Number of pages	9
Journal	BioMetals
Volume	30
Issue number	5
DOIs	https://doi.org/10.1007/s10534-017-0047-5
State	Published - 1 Oct 2017

Bibliographical note

Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.

Keywords

Anti-cancer activity
Cancer cell lines
Pt(II) complexes
Thione ligands

ASJC Scopus subject areas

Biomaterials
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
Metals and Alloys

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10534-017-0047-5

Cite this

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title = "Synthesis, spectroscopic characterization and in vitro anticancer activity of new platinum(II) complexes with some thione ligands in the presence of triethylphosphine",

abstract = "Seven new platinum(II) complexes (1–7) of triethylphosphine (Et3P) and thiones (L) with general formula, cis-[Pt(Et3P)2(L)2]Cl2 were prepared and characterized by elemental analysis, FTIR and NMR (1H, 13C & 31P) measurements. The analytical and spectroscopic data suggested the formation of the desired complexes. The complexes were tested for in vitro cytotoxicity against four cell lines: Hela (human cervical adenocarcinoma), MCF-7 (human breast carcinoma), A549 (human lung carcinoma), and HTC15 (human colon carcinoma). The anticancer activity values of compounds 1–6 are much better than cisplatin and carboplatin as indicated by their IC50 values.",

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author = "Jomaa, {Mohammed Yagoub} and Muhammed Altaf and Saeed Ahmad and Gaurav Bhatia and Jatinder Singh and Saleh Altuwaijri and Isab, {Anvarhusein A.}",

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T1 - Synthesis, spectroscopic characterization and in vitro anticancer activity of new platinum(II) complexes with some thione ligands in the presence of triethylphosphine

AU - Jomaa, Mohammed Yagoub

AU - Altaf, Muhammed

AU - Ahmad, Saeed

AU - Bhatia, Gaurav

AU - Singh, Jatinder

AU - Altuwaijri, Saleh

AU - Isab, Anvarhusein A.

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Y1 - 2017/10/1

N2 - Seven new platinum(II) complexes (1–7) of triethylphosphine (Et3P) and thiones (L) with general formula, cis-[Pt(Et3P)2(L)2]Cl2 were prepared and characterized by elemental analysis, FTIR and NMR (1H, 13C & 31P) measurements. The analytical and spectroscopic data suggested the formation of the desired complexes. The complexes were tested for in vitro cytotoxicity against four cell lines: Hela (human cervical adenocarcinoma), MCF-7 (human breast carcinoma), A549 (human lung carcinoma), and HTC15 (human colon carcinoma). The anticancer activity values of compounds 1–6 are much better than cisplatin and carboplatin as indicated by their IC50 values.

AB - Seven new platinum(II) complexes (1–7) of triethylphosphine (Et3P) and thiones (L) with general formula, cis-[Pt(Et3P)2(L)2]Cl2 were prepared and characterized by elemental analysis, FTIR and NMR (1H, 13C & 31P) measurements. The analytical and spectroscopic data suggested the formation of the desired complexes. The complexes were tested for in vitro cytotoxicity against four cell lines: Hela (human cervical adenocarcinoma), MCF-7 (human breast carcinoma), A549 (human lung carcinoma), and HTC15 (human colon carcinoma). The anticancer activity values of compounds 1–6 are much better than cisplatin and carboplatin as indicated by their IC50 values.

KW - Anti-cancer activity

KW - Cancer cell lines

KW - Pt(II) complexes

KW - Thione ligands

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