Synthesis, spectroscopic characterization and antimicrobial studies of mercury(II) complexes of thiolates

Ghulam Rabbani; Anvarhusein A. Isab; Abdul Rahman Al-Arfaj; Saeed Ahmad; Muhammad Saleem; Abdul Hameed; Erum Akbar

doi:10.3233/SPE-2009-0369

Synthesis, spectroscopic characterization and antimicrobial studies of mercury(II) complexes of thiolates

Ghulam Rabbani, Anvarhusein A. Isab, Abdul Rahman Al-Arfaj, Saeed Ahmad, Muhammad Saleem, Abdul Hameed, Erum Akbar

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Mercury(II) complexes of thiolates having the general formula [Hg(RS)Cl₂]^- and [Hg(RS)₂] have been prepared and characterized by IR and NMR (¹H and ¹³C) spectroscopy (RSH = 2-aminoethanethiol hydrochloride (Aet), cysteine (Cys), thiosalicylic acid (Ts) and 2-mercaptonicotinic acid (Mnt)). The spectral data suggests that the coordination of thiolates to mercury(II) occurs through the sulfur as indicated by the absence of S-H vibrations in IR and significant downfield shifts in the C-S resonance in ¹³C NMR. However, in Mnt complexes, coordination through both sulfur and nitrogen is indicated. Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited a wide range of activities against gram-negative bacteria (E. coli, P. aeruginosa), while moderate activity was observed against a mold, P. citrinum.

Original language	English
Pages (from-to)	45-50
Number of pages	6
Journal	Spectroscopy
Volume	23
Issue number	1
DOIs	https://doi.org/10.3233/SPE-2009-0369
State	Published - 2009

Keywords

Antimicrobial activity
Mercury(II)
NMR spectroscopy
Thiolates

ASJC Scopus subject areas

Spectroscopy

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10.3233/SPE-2009-0369

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@article{dc364f99bf9c4ddab9252491ff42bff9,

title = "Synthesis, spectroscopic characterization and antimicrobial studies of mercury(II) complexes of thiolates",

abstract = "Mercury(II) complexes of thiolates having the general formula [Hg(RS)Cl2]- and [Hg(RS)2] have been prepared and characterized by IR and NMR (1H and 13C) spectroscopy (RSH = 2-aminoethanethiol hydrochloride (Aet), cysteine (Cys), thiosalicylic acid (Ts) and 2-mercaptonicotinic acid (Mnt)). The spectral data suggests that the coordination of thiolates to mercury(II) occurs through the sulfur as indicated by the absence of S-H vibrations in IR and significant downfield shifts in the C-S resonance in 13C NMR. However, in Mnt complexes, coordination through both sulfur and nitrogen is indicated. Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited a wide range of activities against gram-negative bacteria (E. coli, P. aeruginosa), while moderate activity was observed against a mold, P. citrinum.",

keywords = "Antimicrobial activity, Mercury(II), NMR spectroscopy, Thiolates",

author = "Ghulam Rabbani and Isab, \{Anvarhusein A.\} and Al-Arfaj, \{Abdul Rahman\} and Saeed Ahmad and Muhammad Saleem and Abdul Hameed and Erum Akbar",

year = "2009",

doi = "10.3233/SPE-2009-0369",

language = "English",

volume = "23",

pages = "45--50",

journal = "Spectroscopy",

issn = "0712-4813",

publisher = "IOS Press BV",

number = "1",

}

TY - JOUR

T1 - Synthesis, spectroscopic characterization and antimicrobial studies of mercury(II) complexes of thiolates

AU - Rabbani, Ghulam

AU - Isab, Anvarhusein A.

AU - Al-Arfaj, Abdul Rahman

AU - Ahmad, Saeed

AU - Saleem, Muhammad

AU - Hameed, Abdul

AU - Akbar, Erum

PY - 2009

Y1 - 2009

N2 - Mercury(II) complexes of thiolates having the general formula [Hg(RS)Cl2]- and [Hg(RS)2] have been prepared and characterized by IR and NMR (1H and 13C) spectroscopy (RSH = 2-aminoethanethiol hydrochloride (Aet), cysteine (Cys), thiosalicylic acid (Ts) and 2-mercaptonicotinic acid (Mnt)). The spectral data suggests that the coordination of thiolates to mercury(II) occurs through the sulfur as indicated by the absence of S-H vibrations in IR and significant downfield shifts in the C-S resonance in 13C NMR. However, in Mnt complexes, coordination through both sulfur and nitrogen is indicated. Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited a wide range of activities against gram-negative bacteria (E. coli, P. aeruginosa), while moderate activity was observed against a mold, P. citrinum.

AB - Mercury(II) complexes of thiolates having the general formula [Hg(RS)Cl2]- and [Hg(RS)2] have been prepared and characterized by IR and NMR (1H and 13C) spectroscopy (RSH = 2-aminoethanethiol hydrochloride (Aet), cysteine (Cys), thiosalicylic acid (Ts) and 2-mercaptonicotinic acid (Mnt)). The spectral data suggests that the coordination of thiolates to mercury(II) occurs through the sulfur as indicated by the absence of S-H vibrations in IR and significant downfield shifts in the C-S resonance in 13C NMR. However, in Mnt complexes, coordination through both sulfur and nitrogen is indicated. Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited a wide range of activities against gram-negative bacteria (E. coli, P. aeruginosa), while moderate activity was observed against a mold, P. citrinum.

KW - Antimicrobial activity

KW - Mercury(II)

KW - NMR spectroscopy

KW - Thiolates

UR - https://www.scopus.com/pages/publications/63849252022

U2 - 10.3233/SPE-2009-0369

DO - 10.3233/SPE-2009-0369

M3 - Article

AN - SCOPUS:63849252022

SN - 0712-4813

VL - 23

SP - 45

EP - 50

JO - Spectroscopy

JF - Spectroscopy

IS - 1

ER -

Synthesis, spectroscopic characterization and antimicrobial studies of mercury(II) complexes of thiolates

Abstract

Keywords

ASJC Scopus subject areas

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