Abstract
We disclose herein a metal-free cascade reductive Friedel-Crafts alkylation/cyclization of keto acids/esters for the synthesis of tetralones and indanones. Owing to the simple reaction conditions and setup, this protocol features broad substrate generality, facile scalability, and remarkable functional group tolerance, including the synthesis of bioactive molecule sertraline.
| Original language | English |
|---|---|
| Pages (from-to) | 9274-9277 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 60 |
| Issue number | 69 |
| DOIs | |
| State | Published - 5 Aug 2024 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2024 The Royal Society of Chemistry.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Catalysis
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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