Synthesis of new fused heterocyclic 2-quinolones and 3-alkanonyl-4-hydroxy-2-quinolones

Ashraf A. Aly; Alaa A. Hassan; Nasr K. Mohamed; Lamiaa E. Abd El-Haleem; Stefan Bräse; Mika Polamo; Martin Nieger; Alan B. Brown

doi:10.3390/molecules24203782

Synthesis of new fused heterocyclic 2-quinolones and 3-alkanonyl-4-hydroxy-2-quinolones

Ashraf A. Aly^*
, Alaa A. Hassan
, Nasr K. Mohamed
, Lamiaa E. Abd El-Haleem
, Stefan Bräse
, Mika Polamo
, Martin Nieger
, Alan B. Brown

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c⁰]difuro[2,3-c:4,5-c⁰]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl-butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.

Original language	English
Article number	3782
Journal	Molecules
Volume	24
Issue number	20
DOIs	https://doi.org/10.3390/molecules24203782
State	Published - 21 Oct 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 by the authors.

Keywords

3-dichloropyrazine; ANRORC process bis-pyrazinofuro-quinoline; 1
4-diones; NMR; X-ray
4-diphenylbutane-1
6
7-Disubstituted-4-hydroxy-quinoline-2-ones; 2

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules24203782

Cite this

@article{89442a8f3cca40e0a4da252bb48d90d2,

title = "Synthesis of new fused heterocyclic 2-quinolones and 3-alkanonyl-4-hydroxy-2-quinolones",

abstract = "Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c0]difuro[2,3-c:4,5-c0]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl-butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.",

keywords = "3-dichloropyrazine; ANRORC process bis-pyrazinofuro-quinoline; 1, 4-diones; NMR; X-ray, 4-diphenylbutane-1, 6, 7-Disubstituted-4-hydroxy-quinoline-2-ones; 2",

author = "Aly, \{Ashraf A.\} and Hassan, \{Alaa A.\} and Mohamed, \{Nasr K.\} and \{Abd El-Haleem\}, \{Lamiaa E.\} and Stefan Br{\"a}se and Mika Polamo and Martin Nieger and Brown, \{Alan B.\}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors.",

year = "2019",

month = oct,

day = "21",

doi = "10.3390/molecules24203782",

language = "English",

volume = "24",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "20",

}

TY - JOUR

T1 - Synthesis of new fused heterocyclic 2-quinolones and 3-alkanonyl-4-hydroxy-2-quinolones

AU - Aly, Ashraf A.

AU - Hassan, Alaa A.

AU - Mohamed, Nasr K.

AU - Abd El-Haleem, Lamiaa E.

AU - Bräse, Stefan

AU - Polamo, Mika

AU - Nieger, Martin

AU - Brown, Alan B.

PY - 2019/10/21

Y1 - 2019/10/21

N2 - Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c0]difuro[2,3-c:4,5-c0]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl-butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.

AB - Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c0]difuro[2,3-c:4,5-c0]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl-butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.

KW - 3-dichloropyrazine; ANRORC process bis-pyrazinofuro-quinoline; 1

KW - 4-diones; NMR; X-ray

KW - 4-diphenylbutane-1

KW - 6

KW - 7-Disubstituted-4-hydroxy-quinoline-2-ones; 2

UR - https://www.scopus.com/pages/publications/85073733082

U2 - 10.3390/molecules24203782

DO - 10.3390/molecules24203782

M3 - Article

C2 - 31640196

AN - SCOPUS:85073733082

SN - 1420-3049

VL - 24

JO - Molecules

JF - Molecules

IS - 20

M1 - 3782

ER -

Synthesis of new fused heterocyclic 2-quinolones and 3-alkanonyl-4-hydroxy-2-quinolones

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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