TY - JOUR
T1 - Synthesis of N-substituted derivatives of N-(4-(N-(5-Chloro-2 methoxyphenyl)sulfamoyl)phenyl)acetamide with potential antiurease activity
AU - Aziz-Ur-Rehman,
AU - Ayoub, Maria
AU - Abbasi, Muhammad Athar
AU - Gul, Samreen
AU - Ashraf, Muhammad
AU - Hassan, Rabia
AU - Ahmad, Irshad
AU - Khan, Khalid Mohammed
PY - 2013/12
Y1 - 2013/12
N2 - In this study, a new series of N-alkyl/arakyl derivatives of N-(4-(N-(5-chloro-2-methoxyphenyl)sulfamoyl)phenyl)acetamide (5a-k) was synthesized and screened for enzyme inhibition activity. Target compounds, N-alkyl/arakyl sulfamoylacetamides (5a-k) were synthesized by stirring N-(4-(N-(5-chloro-2-methoxyphenyl)sulfamoyl)phenyl)acetamide (3) with different electrophiles (4a-k) in the presence of sodium hydride (NaH) and N, N-dimethylformamide (DMF). The structures of all the synthesized compounds have been deduced from their spectral (1H-NMR, IR, EI-MS) data. All the new compounds displayed antiurease activity to varying degree.
AB - In this study, a new series of N-alkyl/arakyl derivatives of N-(4-(N-(5-chloro-2-methoxyphenyl)sulfamoyl)phenyl)acetamide (5a-k) was synthesized and screened for enzyme inhibition activity. Target compounds, N-alkyl/arakyl sulfamoylacetamides (5a-k) were synthesized by stirring N-(4-(N-(5-chloro-2-methoxyphenyl)sulfamoyl)phenyl)acetamide (3) with different electrophiles (4a-k) in the presence of sodium hydride (NaH) and N, N-dimethylformamide (DMF). The structures of all the synthesized compounds have been deduced from their spectral (1H-NMR, IR, EI-MS) data. All the new compounds displayed antiurease activity to varying degree.
KW - 1H-NMR
KW - 2-amino-4-chloroanisol
KW - 4-acetamidobenzenesulfonyl chloride
KW - EI-MS
KW - IR
KW - Urease
UR - https://www.scopus.com/pages/publications/84893863341
M3 - Article
AN - SCOPUS:84893863341
SN - 0253-5106
VL - 35
SP - 1516
EP - 1521
JO - Journal of the Chemical Society of Pakistan
JF - Journal of the Chemical Society of Pakistan
IS - 6
ER -