Synthesis of co-polymeric network of carbopol-g-methacrylic acid nanogels drug carrier system for gastro-protective delivery of ketoprofen and its evaluation

Rai Muhammad Sarfraz; Muhammad Usman Khan; Asif Mahmood; Muhammad Rouf Akram; Muhammad Usman Minhas; Muhammad Naeem QAISAR; Muhammad Rizwan ALI; Hasnain Ahmad; Muhammad Zaman

doi:10.1080/25740881.2020.1719148

Synthesis of co-polymeric network of carbopol-g-methacrylic acid nanogels drug carrier system for gastro-protective delivery of ketoprofen and its evaluation

Rai Muhammad Sarfraz^*, Muhammad Usman Khan, Asif Mahmood, Muhammad Rouf Akram, Muhammad Usman Minhas, Muhammad Naeem QAISAR, Muhammad Rizwan ALI, Hasnain Ahmad, Muhammad Zaman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Hydrogels nanoparticles of carbopol were prepared by free-radical polymerization technique. Methacrylic acid (MAA) imparted the pH-sensitive response to formulations. pH-sensitive behavior of the prepared formulations was evaluated by swelling index of the formulations at different pH 1.2 and 7.4 and it presented the maximum swelling index at pH 7.4. It was evident from the release behavior of drugs that maximum drug release was at higher pH 7.4, and less drug release at lower pH 1.2 that is acidic. Results of nanogels carrier systems are the indications of gastro-protective drug delivery of gastric irritant agent, ketoprofen.

Original language	English
Pages (from-to)	1109-1123
Number of pages	15
Journal	Polymer-Plastics Technology and Materials
Volume	59
Issue number	10
DOIs	https://doi.org/10.1080/25740881.2020.1719148
State	Published - 2 Jul 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020, © 2020 Taylor & Francis.

Keywords

Carbopol
free radical polymerization
ketoprofen
methacrylic acid
nanogels

ASJC Scopus subject areas

General Chemical Engineering
Polymers and Plastics
Materials Chemistry

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10.1080/25740881.2020.1719148

Cite this

Sarfraz, R. M., Khan, M. U., Mahmood, A., Akram, M. R., Minhas, M. U., QAISAR, M. N., ALI, M. R., Ahmad, H., & Zaman, M. (2020). Synthesis of co-polymeric network of carbopol-g-methacrylic acid nanogels drug carrier system for gastro-protective delivery of ketoprofen and its evaluation. Polymer-Plastics Technology and Materials, 59(10), 1109-1123. https://doi.org/10.1080/25740881.2020.1719148

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abstract = "Hydrogels nanoparticles of carbopol were prepared by free-radical polymerization technique. Methacrylic acid (MAA) imparted the pH-sensitive response to formulations. pH-sensitive behavior of the prepared formulations was evaluated by swelling index of the formulations at different pH 1.2 and 7.4 and it presented the maximum swelling index at pH 7.4. It was evident from the release behavior of drugs that maximum drug release was at higher pH 7.4, and less drug release at lower pH 1.2 that is acidic. Results of nanogels carrier systems are the indications of gastro-protective drug delivery of gastric irritant agent, ketoprofen.",

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doi = "10.1080/25740881.2020.1719148",

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Sarfraz, RM, Khan, MU, Mahmood, A, Akram, MR, Minhas, MU, QAISAR, MN, ALI, MR, Ahmad, H & Zaman, M 2020, 'Synthesis of co-polymeric network of carbopol-g-methacrylic acid nanogels drug carrier system for gastro-protective delivery of ketoprofen and its evaluation', Polymer-Plastics Technology and Materials, vol. 59, no. 10, pp. 1109-1123. https://doi.org/10.1080/25740881.2020.1719148

Synthesis of co-polymeric network of carbopol-g-methacrylic acid nanogels drug carrier system for gastro-protective delivery of ketoprofen and its evaluation. / Sarfraz, Rai Muhammad; Khan, Muhammad Usman; Mahmood, Asif et al.
In: Polymer-Plastics Technology and Materials, Vol. 59, No. 10, 02.07.2020, p. 1109-1123.

Research output: Contribution to journal › Article › peer-review

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AU - Sarfraz, Rai Muhammad

AU - Khan, Muhammad Usman

AU - Mahmood, Asif

AU - Akram, Muhammad Rouf

AU - Minhas, Muhammad Usman

AU - QAISAR, Muhammad Naeem

AU - ALI, Muhammad Rizwan

AU - Ahmad, Hasnain

AU - Zaman, Muhammad

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Synthesis of co-polymeric network of carbopol-g-methacrylic acid nanogels drug carrier system for gastro-protective delivery of ketoprofen and its evaluation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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