Abstract
The Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboronic acids resulted in site-selective formation of 2-aryl-6-chloro-3-(trifluoromethyl)pyridine. Due to electronic reasons, the reaction takes place at the sterically more hindered position. The one-pot reaction with two different arylboronic acids afforded 2,6-diaryl-3- (trifluoromethyl)pyridine containing two different aryl substituents. The reactions proceeded smoothly in the absence of phosphane ligands.
| Original language | English |
|---|---|
| Pages (from-to) | 1669-1672 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 54 |
| Issue number | 13 |
| DOIs | |
| State | Published - 27 Mar 2013 |
| Externally published | Yes |
Bibliographical note
Funding Information:Financial support by the Higher Education Commission Pakistan and by the DAAD (scholarships for S.A. and K.S.) is gratefully acknowledged. Financial support by the European Social Fund (EFRE program) is also acknowledged. The work was also supported by the TÁMOP-4.2.1/B-09/KONV-2010-007 project. The project is implemented through the New Hungary Development Plan, co-financed by the European Social Fund and the European Regional Development Fund.
Keywords
- Catalysis
- Organofluorine compounds
- Palladium
- Regioselectivity
- Suzuki-Miyaura reaction
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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