Synthesis of 1ʹ-Acetoxychavicol Acetate (ACA) Analogues and Their Inhibitory Activities against Methicillin-resistant Staphylococcus aureus

Nursyazwani Anuar; Mohamad Nurul Azmi Mohamad Taib; Khayriyyah Mohd Hanafiah; Aemen Ali Kudayr Al Shammary; Nur Shazieyatul Nadiah Shalan; Siti Nur Izaty Che Humaidi; Khalijah Awang

doi:10.21315/jps2020.31.3.8

Synthesis of 1ʹ-Acetoxychavicol Acetate (ACA) Analogues and Their Inhibitory Activities against Methicillin-resistant Staphylococcus aureus

Nursyazwani Anuar
, Mohamad Nurul Azmi Mohamad Taib^*
, Khayriyyah Mohd Hanafiah
, Aemen Ali Kudayr Al Shammary
, Nur Shazieyatul Nadiah Shalan
, Siti Nur Izaty Che Humaidi
, Khalijah Awang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A series of 1ʹ-acetoxychavicol acetate analogues were synthesised and evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) using broth microdilution technique. The minimum inhibitory concentration (MIC) was used to determine whether the compounds had potential as inhibitory agents against the MRSA ATCC 43300, and the compounds with antimicrobial potential (<2000 μg ml^–1) were tested for minimum bactericidal concentration (MBC). Based on this assay, compound 1 exhibited potent antimicrobial activity with MIC value of 250 μg ml–1. Meanwhile, compounds 2 and 13 showed the moderate activity with MIC values of 500 μg ml^–1, respectively.

Original language	English
Pages (from-to)	101-111
Number of pages	11
Journal	Journal of Physical Science
Volume	31
Issue number	3
DOIs	https://doi.org/10.21315/jps2020.31.3.8
State	Published - 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020. All rights reserved.

Keywords

1‘-acetoxychavicol acetate analogues
antimicrobial activity
methicillin-resistant Staphylococcus aureus
minimum bactericidal concentration
minimum inhibitory concentration

ASJC Scopus subject areas

General Materials Science
General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21315/jps2020.31.3.8

Cite this

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title = "Synthesis of 1ʹ-Acetoxychavicol Acetate (ACA) Analogues and Their Inhibitory Activities against Methicillin-resistant Staphylococcus aureus",

abstract = "A series of 1ʹ-acetoxychavicol acetate analogues were synthesised and evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) using broth microdilution technique. The minimum inhibitory concentration (MIC) was used to determine whether the compounds had potential as inhibitory agents against the MRSA ATCC 43300, and the compounds with antimicrobial potential (<2000 μg ml–1) were tested for minimum bactericidal concentration (MBC). Based on this assay, compound 1 exhibited potent antimicrobial activity with MIC value of 250 μg ml–1. Meanwhile, compounds 2 and 13 showed the moderate activity with MIC values of 500 μg ml–1, respectively.",

keywords = "1{\textquoteleft}-acetoxychavicol acetate analogues, antimicrobial activity, methicillin-resistant Staphylococcus aureus, minimum bactericidal concentration, minimum inhibitory concentration",

author = "Nursyazwani Anuar and Taib, \{Mohamad Nurul Azmi Mohamad\} and Hanafiah, \{Khayriyyah Mohd\} and Shammary, \{Aemen Ali Kudayr Al\} and Shalan, \{Nur Shazieyatul Nadiah\} and Humaidi, \{Siti Nur Izaty Che\} and Khalijah Awang",

year = "2020",

doi = "10.21315/jps2020.31.3.8",

language = "English",

volume = "31",

pages = "101--111",

journal = "Journal of Physical Science",

issn = "1675-3402",

publisher = "Penerbit Universiti Sains Malaysia",

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T1 - Synthesis of 1ʹ-Acetoxychavicol Acetate (ACA) Analogues and Their Inhibitory Activities against Methicillin-resistant Staphylococcus aureus

AU - Anuar, Nursyazwani

AU - Taib, Mohamad Nurul Azmi Mohamad

AU - Hanafiah, Khayriyyah Mohd

AU - Shammary, Aemen Ali Kudayr Al

AU - Shalan, Nur Shazieyatul Nadiah

AU - Humaidi, Siti Nur Izaty Che

AU - Awang, Khalijah

PY - 2020

Y1 - 2020

N2 - A series of 1ʹ-acetoxychavicol acetate analogues were synthesised and evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) using broth microdilution technique. The minimum inhibitory concentration (MIC) was used to determine whether the compounds had potential as inhibitory agents against the MRSA ATCC 43300, and the compounds with antimicrobial potential (<2000 μg ml–1) were tested for minimum bactericidal concentration (MBC). Based on this assay, compound 1 exhibited potent antimicrobial activity with MIC value of 250 μg ml–1. Meanwhile, compounds 2 and 13 showed the moderate activity with MIC values of 500 μg ml–1, respectively.

AB - A series of 1ʹ-acetoxychavicol acetate analogues were synthesised and evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) using broth microdilution technique. The minimum inhibitory concentration (MIC) was used to determine whether the compounds had potential as inhibitory agents against the MRSA ATCC 43300, and the compounds with antimicrobial potential (<2000 μg ml–1) were tested for minimum bactericidal concentration (MBC). Based on this assay, compound 1 exhibited potent antimicrobial activity with MIC value of 250 μg ml–1. Meanwhile, compounds 2 and 13 showed the moderate activity with MIC values of 500 μg ml–1, respectively.

KW - 1‘-acetoxychavicol acetate analogues

KW - antimicrobial activity

KW - methicillin-resistant Staphylococcus aureus

KW - minimum bactericidal concentration

KW - minimum inhibitory concentration

UR - https://www.scopus.com/pages/publications/85098876577

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DO - 10.21315/jps2020.31.3.8

M3 - Article

AN - SCOPUS:85098876577

SN - 1675-3402

VL - 31

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JO - Journal of Physical Science

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ER -

Synthesis of 1ʹ-Acetoxychavicol Acetate (ACA) Analogues and Their Inhibitory Activities against Methicillin-resistant Staphylococcus aureus

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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