Synthesis, crystal structures and biological activities of palladium(II) complexes of benzimidazole and 2-methylbenzimidazole

Haseeba Sadaf; Imtiaz-ud-Din; Mohammed Fettouhi; Atif Fazal; S. Ahmad; Bilal Ahmad Farooqi; Shafqat Nadeem; Ihsan-ul-Haq; W. Ahmad

doi:10.1016/j.poly.2019.06.025

Synthesis, crystal structures and biological activities of palladium(II) complexes of benzimidazole and 2-methylbenzimidazole

Haseeba Sadaf
, Imtiaz-ud-Din^*
, Mohammed Fettouhi
, Atif Fazal
, S. Ahmad
, Bilal Ahmad Farooqi
, Shafqat Nadeem
, Ihsan-ul-Haq
, W. Ahmad

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Five palladium(II) complexes (1–5) with benzimidazole and 2-methylbenzimidazole were prepared and characterized by thermal analysis and, IR and NMR spectroscopy. The crystal structures of two of them, trans-[Pd(benzimidazole)₂Br₂]·2DMSO (1) and trans-[Pd(2-methylbenzimidazole)₂I₂] (5) were determined by X-ray crystallography, which describe a square planar coordination environment around the Pd(II) ions. Compound 1 crystallizes as a DMSO solvate. The solid state structures of both complexes are stabilized by hydrogen bonding interactions. The biological evaluation of the complexes showed that they exhibited moderate antimicrobial activities but their antidiabetic properties were momentous with respect to the standard drug.

Original language	English
Pages (from-to)	537-543
Number of pages	7
Journal	Polyhedron
Volume	170
DOIs	https://doi.org/10.1016/j.poly.2019.06.025
State	Published - 15 Sep 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

2-Methylbenzimidazole
Benzimidazole
Biological activity
Palladium(II)
X-ray structure

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.poly.2019.06.025

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@article{402081f45a174a8ea5de5e6d376ad779,

title = "Synthesis, crystal structures and biological activities of palladium(II) complexes of benzimidazole and 2-methylbenzimidazole",

abstract = "Five palladium(II) complexes (1–5) with benzimidazole and 2-methylbenzimidazole were prepared and characterized by thermal analysis and, IR and NMR spectroscopy. The crystal structures of two of them, trans-[Pd(benzimidazole)2Br2]·2DMSO (1) and trans-[Pd(2-methylbenzimidazole)2I2] (5) were determined by X-ray crystallography, which describe a square planar coordination environment around the Pd(II) ions. Compound 1 crystallizes as a DMSO solvate. The solid state structures of both complexes are stabilized by hydrogen bonding interactions. The biological evaluation of the complexes showed that they exhibited moderate antimicrobial activities but their antidiabetic properties were momentous with respect to the standard drug.",

keywords = "2-Methylbenzimidazole, Benzimidazole, Biological activity, Palladium(II), X-ray structure",

author = "Haseeba Sadaf and Imtiaz-ud-Din and Mohammed Fettouhi and Atif Fazal and S. Ahmad and Farooqi, \{Bilal Ahmad\} and Shafqat Nadeem and Ihsan-ul-Haq and W. Ahmad",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = sep,

day = "15",

doi = "10.1016/j.poly.2019.06.025",

language = "English",

volume = "170",

pages = "537--543",

journal = "Polyhedron",

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TY - JOUR

T1 - Synthesis, crystal structures and biological activities of palladium(II) complexes of benzimidazole and 2-methylbenzimidazole

AU - Sadaf, Haseeba

AU - Imtiaz-ud-Din,

AU - Fettouhi, Mohammed

AU - Fazal, Atif

AU - Ahmad, S.

AU - Farooqi, Bilal Ahmad

AU - Nadeem, Shafqat

AU - Ihsan-ul-Haq,

AU - Ahmad, W.

PY - 2019/9/15

Y1 - 2019/9/15

N2 - Five palladium(II) complexes (1–5) with benzimidazole and 2-methylbenzimidazole were prepared and characterized by thermal analysis and, IR and NMR spectroscopy. The crystal structures of two of them, trans-[Pd(benzimidazole)2Br2]·2DMSO (1) and trans-[Pd(2-methylbenzimidazole)2I2] (5) were determined by X-ray crystallography, which describe a square planar coordination environment around the Pd(II) ions. Compound 1 crystallizes as a DMSO solvate. The solid state structures of both complexes are stabilized by hydrogen bonding interactions. The biological evaluation of the complexes showed that they exhibited moderate antimicrobial activities but their antidiabetic properties were momentous with respect to the standard drug.

AB - Five palladium(II) complexes (1–5) with benzimidazole and 2-methylbenzimidazole were prepared and characterized by thermal analysis and, IR and NMR spectroscopy. The crystal structures of two of them, trans-[Pd(benzimidazole)2Br2]·2DMSO (1) and trans-[Pd(2-methylbenzimidazole)2I2] (5) were determined by X-ray crystallography, which describe a square planar coordination environment around the Pd(II) ions. Compound 1 crystallizes as a DMSO solvate. The solid state structures of both complexes are stabilized by hydrogen bonding interactions. The biological evaluation of the complexes showed that they exhibited moderate antimicrobial activities but their antidiabetic properties were momentous with respect to the standard drug.

KW - 2-Methylbenzimidazole

KW - Benzimidazole

KW - Biological activity

KW - Palladium(II)

KW - X-ray structure

UR - https://www.scopus.com/pages/publications/85068209483

U2 - 10.1016/j.poly.2019.06.025

DO - 10.1016/j.poly.2019.06.025

M3 - Article

AN - SCOPUS:85068209483

SN - 0277-5387

VL - 170

SP - 537

EP - 543

JO - Polyhedron

JF - Polyhedron

ER -

Synthesis, crystal structures and biological activities of palladium(II) complexes of benzimidazole and 2-methylbenzimidazole

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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