Synthesis, crystal structure and antimicrobial studies of a thione derivative of transplatin, trans-[Pt(NH3)2(Diaz) 2]Cl2·2H2O (Diaz = 1,3-diazinane-2- thione)

Seerat-Ur-Rehman; Anvarhusein A. Isab; Muhammad Nawaz Tahir; Tanzeel Khalid; Muhammad Saleem; Haseeba Sadaf; Saeed Ahmad

doi:10.1016/j.inoche.2013.08.019

Synthesis, crystal structure and antimicrobial studies of a thione derivative of transplatin, trans-[Pt(NH₃)₂(Diaz) ₂]Cl₂·2H₂O (Diaz = 1,3-diazinane-2- thione)

Seerat-Ur-Rehman
, Anvarhusein A. Isab
, Muhammad Nawaz Tahir
, Tanzeel Khalid
, Muhammad Saleem
, Haseeba Sadaf
, Saeed Ahmad^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Platinum(II) complexes, trans-[Pt(NH₃)₂(Diaz) ₂]Cl₂·2H₂O (1) and trans-[Pt(NH ₃)₂(Tu)₂]Cl₂ (Diaz = 1,3-diazinane-2-thione, Tu = thiourea) were prepared and characterized by elemental analysis, IR and NMR spectroscopy. The crystal structure of compound 1 was determined by X-ray crystallography. The structure of 1 consists of trans-[Pt(NH₃)₂(Diaz)₂]^{2 +} cation, two chloride ions and two water molecules. In trans-[Pt(NH₃) ₂(Diaz)₂]^{2 +}, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 180 respectively. The ¹H and ¹³C NMR spectral data indicated the coordination of both ligands to platinum(II). Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited significant activities against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). However, moderate activity was observed against molds (Aspergillus niger, Penicillium citrinum).

Original language	English
Pages (from-to)	68-71
Number of pages	4
Journal	Inorganic Chemistry Communication
Volume	36
DOIs	https://doi.org/10.1016/j.inoche.2013.08.019
State	Published - 2013

Keywords

1,3-Diazinane-2-thione
Keywords Platinum(II) complexes
Thiourea -ray structure
Transplatin

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1016/j.inoche.2013.08.019

Cite this

@article{7f4bae6ba6f24452b164d374b84d8610,

title = "Synthesis, crystal structure and antimicrobial studies of a thione derivative of transplatin, trans-[Pt(NH3)2(Diaz) 2]Cl2·2H2O (Diaz = 1,3-diazinane-2- thione)",

abstract = "Platinum(II) complexes, trans-[Pt(NH3)2(Diaz) 2]Cl2·2H2O (1) and trans-[Pt(NH 3)2(Tu)2]Cl2 (Diaz = 1,3-diazinane-2-thione, Tu = thiourea) were prepared and characterized by elemental analysis, IR and NMR spectroscopy. The crystal structure of compound 1 was determined by X-ray crystallography. The structure of 1 consists of trans-[Pt(NH3)2(Diaz)2]2 + cation, two chloride ions and two water molecules. In trans-[Pt(NH3) 2(Diaz)2]2 +, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 180 respectively. The 1H and 13C NMR spectral data indicated the coordination of both ligands to platinum(II). Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited significant activities against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). However, moderate activity was observed against molds (Aspergillus niger, Penicillium citrinum).",

keywords = "1,3-Diazinane-2-thione, Keywords Platinum(II) complexes, Thiourea -ray structure, Transplatin",

author = "Seerat-Ur-Rehman and Isab, \{Anvarhusein A.\} and Tahir, \{Muhammad Nawaz\} and Tanzeel Khalid and Muhammad Saleem and Haseeba Sadaf and Saeed Ahmad",

year = "2013",

doi = "10.1016/j.inoche.2013.08.019",

language = "English",

volume = "36",

pages = "68--71",

journal = "Inorganic Chemistry Communication",

issn = "1387-7003",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Synthesis, crystal structure and antimicrobial studies of a thione derivative of transplatin, trans-[Pt(NH3)2(Diaz) 2]Cl2·2H2O (Diaz = 1,3-diazinane-2- thione)

AU - Seerat-Ur-Rehman,

AU - Isab, Anvarhusein A.

AU - Tahir, Muhammad Nawaz

AU - Khalid, Tanzeel

AU - Saleem, Muhammad

AU - Sadaf, Haseeba

AU - Ahmad, Saeed

PY - 2013

Y1 - 2013

N2 - Platinum(II) complexes, trans-[Pt(NH3)2(Diaz) 2]Cl2·2H2O (1) and trans-[Pt(NH 3)2(Tu)2]Cl2 (Diaz = 1,3-diazinane-2-thione, Tu = thiourea) were prepared and characterized by elemental analysis, IR and NMR spectroscopy. The crystal structure of compound 1 was determined by X-ray crystallography. The structure of 1 consists of trans-[Pt(NH3)2(Diaz)2]2 + cation, two chloride ions and two water molecules. In trans-[Pt(NH3) 2(Diaz)2]2 +, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 180 respectively. The 1H and 13C NMR spectral data indicated the coordination of both ligands to platinum(II). Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited significant activities against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). However, moderate activity was observed against molds (Aspergillus niger, Penicillium citrinum).

AB - Platinum(II) complexes, trans-[Pt(NH3)2(Diaz) 2]Cl2·2H2O (1) and trans-[Pt(NH 3)2(Tu)2]Cl2 (Diaz = 1,3-diazinane-2-thione, Tu = thiourea) were prepared and characterized by elemental analysis, IR and NMR spectroscopy. The crystal structure of compound 1 was determined by X-ray crystallography. The structure of 1 consists of trans-[Pt(NH3)2(Diaz)2]2 + cation, two chloride ions and two water molecules. In trans-[Pt(NH3) 2(Diaz)2]2 +, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 180 respectively. The 1H and 13C NMR spectral data indicated the coordination of both ligands to platinum(II). Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited significant activities against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). However, moderate activity was observed against molds (Aspergillus niger, Penicillium citrinum).

KW - 1,3-Diazinane-2-thione

KW - Keywords Platinum(II) complexes

KW - Thiourea -ray structure

KW - Transplatin

UR - https://www.scopus.com/pages/publications/84883695933

U2 - 10.1016/j.inoche.2013.08.019

DO - 10.1016/j.inoche.2013.08.019

M3 - Article

AN - SCOPUS:84883695933

SN - 1387-7003

VL - 36

SP - 68

EP - 71

JO - Inorganic Chemistry Communication

JF - Inorganic Chemistry Communication

ER -