Synthesis, characterization of mixed ligand palladium(II) complexes of triphenylphosphine and anilines and their enzyme inhibition studies against β-glucuronidase. the crystal structure of trans-dichloro-(m-chloroaniline) (triphenylphosphine)palladium(II)

Maliha Asma; Amin Badshah; Saqib Ali; Manzar Sohail; Mohammed Fettouhi; Saeed Ahmad; Abdul Malik

doi:10.1007/s11243-006-0027-z

Synthesis, characterization of mixed ligand palladium(II) complexes of triphenylphosphine and anilines and their enzyme inhibition studies against β-glucuronidase. the crystal structure of trans-dichloro-(m-chloroaniline) (triphenylphosphine)palladium(II)

Maliha Asma
, Amin Badshah^*
, Saqib Ali
, Manzar Sohail
, Mohammed Fettouhi
, Saeed Ahmad
, Abdul Malik

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A number of palladium(II) complexes with Ph₃P and aromatic amines as ligands having the general formula [(Ph₃P)Pd(Ph ₃P)(NH₂R)Cl₂] {where R = Ph (1), m-ClC ₆H₄ (2), p-ClC₆H₅ (3)} and [Pd(CH₃NHPh)Cl₂] (4), have been synthesized and characterized by elemental analysis, IR, ¹H and ¹³C NMR. The X-ray crystal structure of [(Ph₃P)Pd(m-ClC₆H ₄NH₂)Cl₂] · CH₂ Cl ₂ (2) shows a distorted square planar environment around the Pd(II) ion with the P-Pd-N and Cl(1)-Pd-Cl(2) bond angles of 174.88(5)° and 176.77(2)° respectively. The complexes were screened for enzyme inhibition activity against β-glucuronidase and found to be active.

Original language	English
Pages (from-to)	556-559
Number of pages	4
Journal	Transition Metal Chemistry
Volume	31
Issue number	4
DOIs	https://doi.org/10.1007/s11243-006-0027-z
State	Published - May 2006

ASJC Scopus subject areas

Inorganic Chemistry
Metals and Alloys
Materials Chemistry

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Asma, M., Badshah, A., Ali, S., Sohail, M., Fettouhi, M., Ahmad, S., & Malik, A. (2006). Synthesis, characterization of mixed ligand palladium(II) complexes of triphenylphosphine and anilines and their enzyme inhibition studies against β-glucuronidase. the crystal structure of trans-dichloro-(m-chloroaniline) (triphenylphosphine)palladium(II). Transition Metal Chemistry, 31(4), 556-559. https://doi.org/10.1007/s11243-006-0027-z

Asma, Maliha ; Badshah, Amin ; Ali, Saqib et al. / Synthesis, characterization of mixed ligand palladium(II) complexes of triphenylphosphine and anilines and their enzyme inhibition studies against β-glucuronidase. the crystal structure of trans-dichloro-(m-chloroaniline) (triphenylphosphine)palladium(II). In: Transition Metal Chemistry. 2006 ; Vol. 31, No. 4. pp. 556-559.

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title = "Synthesis, characterization of mixed ligand palladium(II) complexes of triphenylphosphine and anilines and their enzyme inhibition studies against β-glucuronidase. the crystal structure of trans-dichloro-(m-chloroaniline) (triphenylphosphine)palladium(II)",

abstract = "A number of palladium(II) complexes with Ph3P and aromatic amines as ligands having the general formula [(Ph3P)Pd(Ph 3P)(NH2R)Cl2] \{where R = Ph (1), m-ClC 6H4 (2), p-ClC6H5 (3)\} and [Pd(CH3NHPh)Cl2] (4), have been synthesized and characterized by elemental analysis, IR, 1H and 13C NMR. The X-ray crystal structure of [(Ph3P)Pd(m-ClC6H 4NH2)Cl2] · CH2 Cl 2 (2) shows a distorted square planar environment around the Pd(II) ion with the P-Pd-N and Cl(1)-Pd-Cl(2) bond angles of 174.88(5)° and 176.77(2)° respectively. The complexes were screened for enzyme inhibition activity against β-glucuronidase and found to be active.",

author = "Maliha Asma and Amin Badshah and Saqib Ali and Manzar Sohail and Mohammed Fettouhi and Saeed Ahmad and Abdul Malik",

year = "2006",

month = may,

doi = "10.1007/s11243-006-0027-z",

language = "English",

volume = "31",

pages = "556--559",

journal = "Transition Metal Chemistry",

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Asma, M, Badshah, A, Ali, S, Sohail, M, Fettouhi, M, Ahmad, S & Malik, A 2006, 'Synthesis, characterization of mixed ligand palladium(II) complexes of triphenylphosphine and anilines and their enzyme inhibition studies against β-glucuronidase. the crystal structure of trans-dichloro-(m-chloroaniline) (triphenylphosphine)palladium(II)', Transition Metal Chemistry, vol. 31, no. 4, pp. 556-559. https://doi.org/10.1007/s11243-006-0027-z

Synthesis, characterization of mixed ligand palladium(II) complexes of triphenylphosphine and anilines and their enzyme inhibition studies against β-glucuronidase. the crystal structure of trans-dichloro-(m-chloroaniline) (triphenylphosphine)palladium(II). / Asma, Maliha; Badshah, Amin; Ali, Saqib et al.
In: Transition Metal Chemistry, Vol. 31, No. 4, 05.2006, p. 556-559.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis, characterization of mixed ligand palladium(II) complexes of triphenylphosphine and anilines and their enzyme inhibition studies against β-glucuronidase. the crystal structure of trans-dichloro-(m-chloroaniline) (triphenylphosphine)palladium(II)

AU - Asma, Maliha

AU - Badshah, Amin

AU - Ali, Saqib

AU - Sohail, Manzar

AU - Fettouhi, Mohammed

AU - Ahmad, Saeed

AU - Malik, Abdul

PY - 2006/5

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N2 - A number of palladium(II) complexes with Ph3P and aromatic amines as ligands having the general formula [(Ph3P)Pd(Ph 3P)(NH2R)Cl2] {where R = Ph (1), m-ClC 6H4 (2), p-ClC6H5 (3)} and [Pd(CH3NHPh)Cl2] (4), have been synthesized and characterized by elemental analysis, IR, 1H and 13C NMR. The X-ray crystal structure of [(Ph3P)Pd(m-ClC6H 4NH2)Cl2] · CH2 Cl 2 (2) shows a distorted square planar environment around the Pd(II) ion with the P-Pd-N and Cl(1)-Pd-Cl(2) bond angles of 174.88(5)° and 176.77(2)° respectively. The complexes were screened for enzyme inhibition activity against β-glucuronidase and found to be active.

AB - A number of palladium(II) complexes with Ph3P and aromatic amines as ligands having the general formula [(Ph3P)Pd(Ph 3P)(NH2R)Cl2] {where R = Ph (1), m-ClC 6H4 (2), p-ClC6H5 (3)} and [Pd(CH3NHPh)Cl2] (4), have been synthesized and characterized by elemental analysis, IR, 1H and 13C NMR. The X-ray crystal structure of [(Ph3P)Pd(m-ClC6H 4NH2)Cl2] · CH2 Cl 2 (2) shows a distorted square planar environment around the Pd(II) ion with the P-Pd-N and Cl(1)-Pd-Cl(2) bond angles of 174.88(5)° and 176.77(2)° respectively. The complexes were screened for enzyme inhibition activity against β-glucuronidase and found to be active.

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SP - 556

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JO - Transition Metal Chemistry

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Asma M, Badshah A, Ali S, Sohail M, Fettouhi M, Ahmad S et al. Synthesis, characterization of mixed ligand palladium(II) complexes of triphenylphosphine and anilines and their enzyme inhibition studies against β-glucuronidase. the crystal structure of trans-dichloro-(m-chloroaniline) (triphenylphosphine)palladium(II). Transition Metal Chemistry. 2006 May;31(4):556-559. doi: 10.1007/s11243-006-0027-z