Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime

Waqas Mahmood; Irshad Ahmad; Mohsin Abbas Khan; Syed Adnan Ali Shah; Muhammad Ashraf; Mirza Imran Shahzad; Irfan Pervaiz; Muhammad Sajid-ur-Rehman; Umair Khurshid

doi:10.1016/j.heliyon.2022.e11332

Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime

Waqas Mahmood^*
, Irshad Ahmad
, Mohsin Abbas Khan
, Syed Adnan Ali Shah
, Muhammad Ashraf
, Mirza Imran Shahzad
, Irfan Pervaiz
, Muhammad Sajid-ur-Rehman
, Umair Khurshid

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Synthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, ¹HNMR, and ¹³CNMR. Molecular docking against IBV Virus papain-like protease (PLPro) was done with Auto dock tools against compounds having excellent IC₅₀ values against IBV (Corona Class) virus. All derivatives showed strong zone of inhibition ranges from (55 ± 2.0 to 70 ± 0.8 mm) against E. coli. Compounds 1,2,4 and 6 derivatives showed remarkable activity against Stenotrophomonas maltophilia and Serratia marcescens. But For most the newly synthesized derivatives C¹ (64 ± 1.60), C³ (32 ± 0.80), and C⁸ (64 ± 1.60) showed potential IC₅₀ values against two variants of Corona class viruses i.e. Avian Influenza (H9) and Avian corona (IBV) viruses. The current study revealed that newly synthesized Schiff Bases possessed strong anti-viral potential. Further studies may make a breakthrough in medical sciences to tackle latest challenges such as Corona Virus Diseases.

Original language	English
Article number	e11332
Journal	Heliyon
Volume	8
Issue number	11
DOIs	https://doi.org/10.1016/j.heliyon.2022.e11332
State	Published - Nov 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antiviral
Cefpodoxime
Corona virus class
FTIR
NMR (H and C)
Schiff bases

ASJC Scopus subject areas

General

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10.1016/j.heliyon.2022.e11332

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title = "Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime",

abstract = "Synthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, 1HNMR, and 13CNMR. Molecular docking against IBV Virus papain-like protease (PLPro) was done with Auto dock tools against compounds having excellent IC50 values against IBV (Corona Class) virus. All derivatives showed strong zone of inhibition ranges from (55 ± 2.0 to 70 ± 0.8 mm) against E. coli. Compounds 1,2,4 and 6 derivatives showed remarkable activity against Stenotrophomonas maltophilia and Serratia marcescens. But For most the newly synthesized derivatives C1 (64 ± 1.60), C3 (32 ± 0.80), and C8 (64 ± 1.60) showed potential IC50 values against two variants of Corona class viruses i.e. Avian Influenza (H9) and Avian corona (IBV) viruses. The current study revealed that newly synthesized Schiff Bases possessed strong anti-viral potential. Further studies may make a breakthrough in medical sciences to tackle latest challenges such as Corona Virus Diseases.",

keywords = "Antiviral, Cefpodoxime, Corona virus class, FTIR, NMR (H and C), Schiff bases",

author = "Waqas Mahmood and Irshad Ahmad and Khan, \{Mohsin Abbas\} and \{Ali Shah\}, \{Syed Adnan\} and Muhammad Ashraf and Shahzad, \{Mirza Imran\} and Irfan Pervaiz and Muhammad Sajid-ur-Rehman and Umair Khurshid",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = nov,

doi = "10.1016/j.heliyon.2022.e11332",

language = "English",

volume = "8",

journal = "Heliyon",

issn = "2405-8440",

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TY - JOUR

T1 - Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime

AU - Mahmood, Waqas

AU - Ahmad, Irshad

AU - Khan, Mohsin Abbas

AU - Ali Shah, Syed Adnan

AU - Ashraf, Muhammad

AU - Shahzad, Mirza Imran

AU - Pervaiz, Irfan

AU - Sajid-ur-Rehman, Muhammad

AU - Khurshid, Umair

PY - 2022/11

Y1 - 2022/11

N2 - Synthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, 1HNMR, and 13CNMR. Molecular docking against IBV Virus papain-like protease (PLPro) was done with Auto dock tools against compounds having excellent IC50 values against IBV (Corona Class) virus. All derivatives showed strong zone of inhibition ranges from (55 ± 2.0 to 70 ± 0.8 mm) against E. coli. Compounds 1,2,4 and 6 derivatives showed remarkable activity against Stenotrophomonas maltophilia and Serratia marcescens. But For most the newly synthesized derivatives C1 (64 ± 1.60), C3 (32 ± 0.80), and C8 (64 ± 1.60) showed potential IC50 values against two variants of Corona class viruses i.e. Avian Influenza (H9) and Avian corona (IBV) viruses. The current study revealed that newly synthesized Schiff Bases possessed strong anti-viral potential. Further studies may make a breakthrough in medical sciences to tackle latest challenges such as Corona Virus Diseases.

AB - Synthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, 1HNMR, and 13CNMR. Molecular docking against IBV Virus papain-like protease (PLPro) was done with Auto dock tools against compounds having excellent IC50 values against IBV (Corona Class) virus. All derivatives showed strong zone of inhibition ranges from (55 ± 2.0 to 70 ± 0.8 mm) against E. coli. Compounds 1,2,4 and 6 derivatives showed remarkable activity against Stenotrophomonas maltophilia and Serratia marcescens. But For most the newly synthesized derivatives C1 (64 ± 1.60), C3 (32 ± 0.80), and C8 (64 ± 1.60) showed potential IC50 values against two variants of Corona class viruses i.e. Avian Influenza (H9) and Avian corona (IBV) viruses. The current study revealed that newly synthesized Schiff Bases possessed strong anti-viral potential. Further studies may make a breakthrough in medical sciences to tackle latest challenges such as Corona Virus Diseases.

KW - Antiviral

KW - Cefpodoxime

KW - Corona virus class

KW - FTIR

KW - NMR (H and C)

KW - Schiff bases

UR - https://www.scopus.com/pages/publications/85141709338

U2 - 10.1016/j.heliyon.2022.e11332

DO - 10.1016/j.heliyon.2022.e11332

M3 - Article

AN - SCOPUS:85141709338

SN - 2405-8440

VL - 8

JO - Heliyon

JF - Heliyon

IS - 11

M1 - e11332

ER -

Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

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