Synthesis, characterization, lipoxygenase inhibitory activity and in silico molecular docking of biaryl bis(benzenesulfonamide) and indol-3-yl-hydrazide derivatives

Sadaf Mutahir; Muhammad Yar; Muhammad Asim Khan; Nisar Ullah; Sohail Anjum Shahzad; Islam Ullah Khan; Rana Atif Mehmood; Muhammad Ashraf; Rumana Nasar; Eleni Pontiki

doi:10.1007/s13738-014-0573-9

Synthesis, characterization, lipoxygenase inhibitory activity and in silico molecular docking of biaryl bis(benzenesulfonamide) and indol-3-yl-hydrazide derivatives

Sadaf Mutahir
, Muhammad Yar^*
, Muhammad Asim Khan
, Nisar Ullah
, Sohail Anjum Shahzad
, Islam Ullah Khan
, Rana Atif Mehmood
, Muhammad Ashraf
, Rumana Nasar
, Eleni Pontiki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Abstract In this paper, we have screened a library of two different series of compounds to identify potent lipoxygenase (LOX) inhibitors. A number of new biphenyl bis(benzenesulfonamides) 2-3, indol-3-yl-benzenesulfonyl and acetohydrazides 4-5 and indol-3-yl-hydrazinecarboxylate 6 were synthesized and evaluated in vitro for LOX inhibitory activity. Compounds biphenyl bis(benzenesulfonamide) 2a and indol-3-yl-benzenesulfonylhydrazide 4e presented the best anti-LOX activity within these series with IC₅₀ values 96.31 ± 0.18 and 81.21 ± 2.14 μM, respectively. The results were confirmed with docking studies.

Original language	English
Article number	573
Pages (from-to)	1123-1130
Number of pages	8
Journal	Journal of the Iranian Chemical Society
Volume	12
Issue number	6
DOIs	https://doi.org/10.1007/s13738-014-0573-9
State	Published - 1 Jun 2015

Bibliographical note

Publisher Copyright:
© Iranian Chemical Society 2014.

Keywords

Arachidonic acid
Baicalein
Indole derivatives
LOX inhibitors
Protein 1RRH

ASJC Scopus subject areas

General Chemistry

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10.1007/s13738-014-0573-9

Cite this

Mutahir, S., Yar, M., Khan, M. A., Ullah, N., Shahzad, S. A., Khan, I. U., Mehmood, R. A., Ashraf, M., Nasar, R., & Pontiki, E. (2015). Synthesis, characterization, lipoxygenase inhibitory activity and in silico molecular docking of biaryl bis(benzenesulfonamide) and indol-3-yl-hydrazide derivatives. Journal of the Iranian Chemical Society, 12(6), 1123-1130. Article 573. https://doi.org/10.1007/s13738-014-0573-9

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title = "Synthesis, characterization, lipoxygenase inhibitory activity and in silico molecular docking of biaryl bis(benzenesulfonamide) and indol-3-yl-hydrazide derivatives",

abstract = "Abstract In this paper, we have screened a library of two different series of compounds to identify potent lipoxygenase (LOX) inhibitors. A number of new biphenyl bis(benzenesulfonamides) 2-3, indol-3-yl-benzenesulfonyl and acetohydrazides 4-5 and indol-3-yl-hydrazinecarboxylate 6 were synthesized and evaluated in vitro for LOX inhibitory activity. Compounds biphenyl bis(benzenesulfonamide) 2a and indol-3-yl-benzenesulfonylhydrazide 4e presented the best anti-LOX activity within these series with IC50 values 96.31 ± 0.18 and 81.21 ± 2.14 μM, respectively. The results were confirmed with docking studies.",

keywords = "Arachidonic acid, Baicalein, Indole derivatives, LOX inhibitors, Protein 1RRH",

author = "Sadaf Mutahir and Muhammad Yar and Khan, \{Muhammad Asim\} and Nisar Ullah and Shahzad, \{Sohail Anjum\} and Khan, \{Islam Ullah\} and Mehmood, \{Rana Atif\} and Muhammad Ashraf and Rumana Nasar and Eleni Pontiki",

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year = "2015",

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doi = "10.1007/s13738-014-0573-9",

language = "English",

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Mutahir, S, Yar, M, Khan, MA, Ullah, N, Shahzad, SA, Khan, IU, Mehmood, RA, Ashraf, M, Nasar, R & Pontiki, E 2015, 'Synthesis, characterization, lipoxygenase inhibitory activity and in silico molecular docking of biaryl bis(benzenesulfonamide) and indol-3-yl-hydrazide derivatives', Journal of the Iranian Chemical Society, vol. 12, no. 6, 573, pp. 1123-1130. https://doi.org/10.1007/s13738-014-0573-9

Synthesis, characterization, lipoxygenase inhibitory activity and in silico molecular docking of biaryl bis(benzenesulfonamide) and indol-3-yl-hydrazide derivatives. / Mutahir, Sadaf; Yar, Muhammad; Khan, Muhammad Asim et al.
In: Journal of the Iranian Chemical Society, Vol. 12, No. 6, 573, 01.06.2015, p. 1123-1130.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis, characterization, lipoxygenase inhibitory activity and in silico molecular docking of biaryl bis(benzenesulfonamide) and indol-3-yl-hydrazide derivatives

AU - Mutahir, Sadaf

AU - Yar, Muhammad

AU - Khan, Muhammad Asim

AU - Ullah, Nisar

AU - Shahzad, Sohail Anjum

AU - Khan, Islam Ullah

AU - Mehmood, Rana Atif

AU - Ashraf, Muhammad

AU - Nasar, Rumana

AU - Pontiki, Eleni

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Abstract In this paper, we have screened a library of two different series of compounds to identify potent lipoxygenase (LOX) inhibitors. A number of new biphenyl bis(benzenesulfonamides) 2-3, indol-3-yl-benzenesulfonyl and acetohydrazides 4-5 and indol-3-yl-hydrazinecarboxylate 6 were synthesized and evaluated in vitro for LOX inhibitory activity. Compounds biphenyl bis(benzenesulfonamide) 2a and indol-3-yl-benzenesulfonylhydrazide 4e presented the best anti-LOX activity within these series with IC50 values 96.31 ± 0.18 and 81.21 ± 2.14 μM, respectively. The results were confirmed with docking studies.

AB - Abstract In this paper, we have screened a library of two different series of compounds to identify potent lipoxygenase (LOX) inhibitors. A number of new biphenyl bis(benzenesulfonamides) 2-3, indol-3-yl-benzenesulfonyl and acetohydrazides 4-5 and indol-3-yl-hydrazinecarboxylate 6 were synthesized and evaluated in vitro for LOX inhibitory activity. Compounds biphenyl bis(benzenesulfonamide) 2a and indol-3-yl-benzenesulfonylhydrazide 4e presented the best anti-LOX activity within these series with IC50 values 96.31 ± 0.18 and 81.21 ± 2.14 μM, respectively. The results were confirmed with docking studies.

KW - Arachidonic acid

KW - Baicalein

KW - Indole derivatives

KW - LOX inhibitors

KW - Protein 1RRH

UR - https://www.scopus.com/pages/publications/84928553554

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DO - 10.1007/s13738-014-0573-9

M3 - Article

AN - SCOPUS:84928553554

SN - 1735-207X

VL - 12

SP - 1123

EP - 1130

JO - Journal of the Iranian Chemical Society

JF - Journal of the Iranian Chemical Society

IS - 6

M1 - 573

ER -

Synthesis, characterization, lipoxygenase inhibitory activity and in silico molecular docking of biaryl bis(benzenesulfonamide) and indol-3-yl-hydrazide derivatives

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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