TY - JOUR
T1 - Synthesis, characterization, DFT optimization and anticancer evaluation of phosphanegold(I) dithiocarbamates
AU - Sulaiman, Adam A.
AU - Zierkiewicz, Wiktor
AU - Michalczyk, Mariusz
AU - Malik-Gajewska, Magdalena
AU - Ahmad, Saeed
AU - Alhoshani, Ali
AU - As Sobeai, Homood M.
AU - Bieńko, Dariusz
AU - Isab, Anvarhusein A.
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/10/15
Y1 - 2020/10/15
N2 - Six phosphanegold(I)-dithiocarbamate complexes (1–6) of general formula [Au(L)(S2CNR2)] (where L = 2-(di-isopropylphosphanyl)-1-aminoethane (AEP) and 3-(di-isopropylphosphanyl)-1-aminopropane (APP), and R = methyl, ethyl, benzyl) were prepared by the reactions of equimolar amounts of (CH3)2S–AuCl, phosphanes and dithiocarbamates (S2CNR2) in dichloromethane. The complexes were characterized by elemental analysis, FTIR and NMR spectroscopy. The structures of the complexes were predicted theoretically in the gas phase as well as in chloroform solution using the DFT (density functional theory) methodology. The in vitro cytotoxicity of the complexes was investigated against three human cancer cell lines; A549, HeLa and HepG2. In most of the cases, the inhibition effect of the complexes is less than that of cisplatin. Two of the six tested complexes (3 and 5) showed excellent in vitro cytotoxicity for HepG2 and A549 cells respectively.
AB - Six phosphanegold(I)-dithiocarbamate complexes (1–6) of general formula [Au(L)(S2CNR2)] (where L = 2-(di-isopropylphosphanyl)-1-aminoethane (AEP) and 3-(di-isopropylphosphanyl)-1-aminopropane (APP), and R = methyl, ethyl, benzyl) were prepared by the reactions of equimolar amounts of (CH3)2S–AuCl, phosphanes and dithiocarbamates (S2CNR2) in dichloromethane. The complexes were characterized by elemental analysis, FTIR and NMR spectroscopy. The structures of the complexes were predicted theoretically in the gas phase as well as in chloroform solution using the DFT (density functional theory) methodology. The in vitro cytotoxicity of the complexes was investigated against three human cancer cell lines; A549, HeLa and HepG2. In most of the cases, the inhibition effect of the complexes is less than that of cisplatin. Two of the six tested complexes (3 and 5) showed excellent in vitro cytotoxicity for HepG2 and A549 cells respectively.
KW - Aminophosphanes
KW - Anticancer activity
KW - DFT calculations
KW - Dithiocarbamates
KW - Gold(I)
UR - https://www.scopus.com/pages/publications/85085658408
U2 - 10.1016/j.molstruc.2020.128486
DO - 10.1016/j.molstruc.2020.128486
M3 - Article
AN - SCOPUS:85085658408
SN - 0022-2860
VL - 1218
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
M1 - 128486
ER -
