Synthesis, Characterization, and in vitro Cytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

Adam A.A. Sulaiman; Muhammad Altaf; Anvarhusein A. Isab; Abdullah Alawad; Saleh Altuwaijri; Saeed Ahmad

doi:10.1002/zaac.201600278

Synthesis, Characterization, and in vitro Cytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

Adam A.A. Sulaiman
, Muhammad Altaf
, Anvarhusein A. Isab^*
, Abdullah Alawad
, Saleh Altuwaijri
, Saeed Ahmad

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Gold(I) complexes of 2-(diphenylphosphanyl)ethylamine or (2-aminoethyl)diphenylphosphine (AEP), and dithiocaarbamates (R₂NCS₂) were prepared by the reaction of these ligands with (CH₃)₂S-AuCl in dichloromethane. The synthesized complexes [Au(AEP)Cl] (1), [Au(AEP)₂]Cl (2), and [Au₂(R₂NCS₂)₂]_n(R₂= dimethyl (3), diethyl (4), and dibenzyl (5)) were characterized by elemental analysis, IR,¹H,¹³C and³¹P NMR spectroscopy. The complexes were evaluated for anticancer activity against three cancer cells, A549 (human lung carcinoma), HCT15 (human colon cancer), and MCF7 (human breast cancer) cell lines. Three of the five tested complexes showed significant in vitro cytotoxicity and for A549, the inhibition effect of three compounds is greater than cisplatin.

Original language	English
Pages (from-to)	1454-1459
Number of pages	6
Journal	Zeitschrift fur Anorganische und Allgemeine Chemie
Volume	642
Issue number	24
DOIs	https://doi.org/10.1002/zaac.201600278
State	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer activities
Dithiocarbamate
Gold
Spectroscopy

ASJC Scopus subject areas

Inorganic Chemistry

Access to Document

10.1002/zaac.201600278

Cite this

@article{8a488077cf8d460b976abb3ecddbe8af,

title = "Synthesis, Characterization, and in vitro Cytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates",

abstract = "Gold(I) complexes of 2-(diphenylphosphanyl)ethylamine or (2-aminoethyl)diphenylphosphine (AEP), and dithiocaarbamates (R2NCS2) were prepared by the reaction of these ligands with (CH3)2S-AuCl in dichloromethane. The synthesized complexes [Au(AEP)Cl] (1), [Au(AEP)2]Cl (2), and [Au2(R2NCS2)2]n(R2= dimethyl (3), diethyl (4), and dibenzyl (5)) were characterized by elemental analysis, IR,1H,13C and31P NMR spectroscopy. The complexes were evaluated for anticancer activity against three cancer cells, A549 (human lung carcinoma), HCT15 (human colon cancer), and MCF7 (human breast cancer) cell lines. Three of the five tested complexes showed significant in vitro cytotoxicity and for A549, the inhibition effect of three compounds is greater than cisplatin.",

keywords = "Anticancer activities, Dithiocarbamate, Gold, Spectroscopy",

author = "Sulaiman, \{Adam A.A.\} and Muhammad Altaf and Isab, \{Anvarhusein A.\} and Abdullah Alawad and Saleh Altuwaijri and Saeed Ahmad",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2016",

doi = "10.1002/zaac.201600278",

language = "English",

volume = "642",

pages = "1454--1459",

journal = "Zeitschrift fur Anorganische und Allgemeine Chemie",

issn = "0044-2313",

publisher = "Wiley-VCH Verlag",

number = "24",

}

TY - JOUR

T1 - Synthesis, Characterization, and in vitro Cytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

AU - Sulaiman, Adam A.A.

AU - Altaf, Muhammad

AU - Isab, Anvarhusein A.

AU - Alawad, Abdullah

AU - Altuwaijri, Saleh

AU - Ahmad, Saeed

PY - 2016

Y1 - 2016

N2 - Gold(I) complexes of 2-(diphenylphosphanyl)ethylamine or (2-aminoethyl)diphenylphosphine (AEP), and dithiocaarbamates (R2NCS2) were prepared by the reaction of these ligands with (CH3)2S-AuCl in dichloromethane. The synthesized complexes [Au(AEP)Cl] (1), [Au(AEP)2]Cl (2), and [Au2(R2NCS2)2]n(R2= dimethyl (3), diethyl (4), and dibenzyl (5)) were characterized by elemental analysis, IR,1H,13C and31P NMR spectroscopy. The complexes were evaluated for anticancer activity against three cancer cells, A549 (human lung carcinoma), HCT15 (human colon cancer), and MCF7 (human breast cancer) cell lines. Three of the five tested complexes showed significant in vitro cytotoxicity and for A549, the inhibition effect of three compounds is greater than cisplatin.

AB - Gold(I) complexes of 2-(diphenylphosphanyl)ethylamine or (2-aminoethyl)diphenylphosphine (AEP), and dithiocaarbamates (R2NCS2) were prepared by the reaction of these ligands with (CH3)2S-AuCl in dichloromethane. The synthesized complexes [Au(AEP)Cl] (1), [Au(AEP)2]Cl (2), and [Au2(R2NCS2)2]n(R2= dimethyl (3), diethyl (4), and dibenzyl (5)) were characterized by elemental analysis, IR,1H,13C and31P NMR spectroscopy. The complexes were evaluated for anticancer activity against three cancer cells, A549 (human lung carcinoma), HCT15 (human colon cancer), and MCF7 (human breast cancer) cell lines. Three of the five tested complexes showed significant in vitro cytotoxicity and for A549, the inhibition effect of three compounds is greater than cisplatin.

KW - Anticancer activities

KW - Dithiocarbamate

KW - Gold

KW - Spectroscopy

UR - https://www.scopus.com/pages/publications/84996791587

U2 - 10.1002/zaac.201600278

DO - 10.1002/zaac.201600278

M3 - Article

AN - SCOPUS:84996791587

SN - 0044-2313

VL - 642

SP - 1454

EP - 1459

JO - Zeitschrift fur Anorganische und Allgemeine Chemie

JF - Zeitschrift fur Anorganische und Allgemeine Chemie

IS - 24

ER -

Synthesis, Characterization, and in vitro Cytotoxicity of Gold(I) Complexes of 2-(Diphenylphosphanyl)ethylamine and Dithiocarbamates

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this