Abstract
Isatin is synthetically a versatile substrate that can be used for the synthesis of large variety of heterocyclic compounds. 5-substituted isatins were treated with 2-amino-5-chlorobenzo phenone to form Schiff's bases. Spirothiozolidin-4-ones and 5'-methyl-spiro-4-thiazolidiones were synthesized Schiff's bases of isatins by treating with thioglycolic acid and thiolactic acid, respectively in the presence of 1,4-dioxane and anhydrous zinc chloride. The structures of the synthesized compounds were characterized by elemental and spectral analysis. These compounds were screened for their antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl method. Compound A02 found to possess potent antioxidant activity compared to the standards ascorbic acid and butylated hydroxytoluene.
| Original language | English |
|---|---|
| Pages (from-to) | 641-645 |
| Number of pages | 5 |
| Journal | Indian Journal of Pharmaceutical Sciences |
| Volume | 79 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2017 |
| Externally published | Yes |
Keywords
- 2-amino-5-chlorobenzophenone
- 5-substituted isatins
- Antioxidant activity
ASJC Scopus subject areas
- Pharmaceutical Science