Synthesis, characterization and biological evaluation of N'-substituted-2-(5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazide derivatives

Hydrazone derivatives bearing heterocyclic moiety have been synthesized to evaluate their antibacterial and enzyme inhibition activity. Two p-substituted carboxylic acids (1a and 1b) have been utilized to synthesize ethyl esters (2a and 2b), carbohydrazides (3a and 3b), 5- substituted-1,3,4-oxadiazol-2-thiols (4a and 4b), heterocyclic ethyl esters (5a and 5b) and finally acetohydrazides (6a and 6b). The final hydrazone derivatives, 8a-j and 9a-j, were synthesized by the reaction of 6a and 6b with different un/mono substituted benzaldehydes (7a-j) in methanol. The synthesized compounds were characterized by spectral data of IR, ¹H-NMR and EIMS. The evaluation of these molecules for their antibacterial and lipoxygenase inhibition activities rendered 8g suitable antibacterial agent and lipoxygenase inhibitor and the remaining ones as moderate inhibitors.