Synthesis, characterization and antimicrobial activity of spiro-4-thiazolidione derivatives from 5-substituted indole-2,3-dione

In the present study, a series of 5-fluro and 5-Iodo indole-2,3-dione based spiro-4-thiazolidiones was synthesized, characterization and evaluated for their antimicrobial activity. Condensation of 5-fluro and 5-Iodo indole-2,3-dione with substituted primary aryl amine to give a Schiffbases (A05, A06) which on reaction with thioglycolic acid and thiolactic acid in 1,4-dioxane afforded the formation of the corresponding 4-thiazolidinones (D05, D06, E05 and E06). All the synthesized compounds were characterized on the basis of their IR, ¹H and ¹³C NMR and elemental analysis. The antimicrobial activity of all the compounds (A05, A06, D05, D06, E05 and E06) showed significant activity against all the bacteria and fungus.