TY - JOUR
T1 - Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri- tert -butylphosphine and dialkyl dithiocarbamate ligands
AU - Altaf, Muhammad
AU - Monim-Ul-Mehboob, M.
AU - Seliman, Adam A.A.
AU - Sohail, Manzar
AU - Wazeer, Mohammed I.M.
AU - Isab, Anvarhusein A.
AU - Li, L.
AU - Dhuna, V.
AU - Bhatia, G.
AU - Dhuna, K.
N1 - Publisher Copyright:
© 2015 Elsevier Masson SAS.
PY - 2015/5/5
Y1 - 2015/5/5
N2 - Two new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested.
AB - Two new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested.
KW - Anticancer activity
KW - Gold(I) complexes
KW - Human A549
KW - MCF7 and HeLa cell lines
UR - http://www.scopus.com/inward/record.url?scp=84964296353&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2015.03.019
DO - 10.1016/j.ejmech.2015.03.019
M3 - Article
C2 - 25841201
AN - SCOPUS:84964296353
SN - 0223-5234
VL - 95
SP - 464
EP - 472
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
ER -
