TY - JOUR
T1 - Synthesis, anticancer activity and apoptosis induction of gold(I) complexes containing tris(o-methoxyphenyl)phosphane
AU - Sulaiman, Adam A.A.
AU - Alhoshani, Ali
AU - Ahmad, Saeed
AU - Peedikakkal, Abdul Malik Puthan
AU - Abogosh, Ahmed K.
AU - Alghanem, Meshal
AU - Mahmoud, Mohamed A.
AU - Alanazi, W. A.
AU - Alasmael, Noura
AU - Monim-ul-Mehboob, Muhammad
AU - Isab, Anvarhusein A.
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Four new phosphanegold(I) complexes; [Au{(o-MeO-Ph)3P}Cl] (1), [Au{(o-MeO-Ph)3P}{(Me-Et-Ph)P}]Cl (2), [Au{(o-MeO-Ph)3P}(Ph3P)]Cl (3) and [Au{(o-MeO-Ph)3P}2]Cl (4) (where o-MeO-Ph)3P = tris(o-methoxyphenyl)phosphane and (Me-Et-Ph)P = methylethylphenylphosphane) were prepared and characterized by elemental analysis, FTIR and NMR spectroscopy. The structure of one of the complexes was determined by X-ray crystallography, which showed that the gold(I) atom is linearly coordinated to the phosphorus and Cl atoms. The in vitro cytotoxicity of the complexes was investigated against four human cancer cell lines; A549, HeLa, MDA-MB-231 and MCF7. In all cases, the tested complexes showed excellent cytotoxicity for the selected cells, with IC50 values much less than cisplatin. In order to know the possible mode of cell death, complex 1 was further evaluated for induction of apoptosis towards the A549 cells. The results indicated that the apoptosis induction increases with the complex concentration.
AB - Four new phosphanegold(I) complexes; [Au{(o-MeO-Ph)3P}Cl] (1), [Au{(o-MeO-Ph)3P}{(Me-Et-Ph)P}]Cl (2), [Au{(o-MeO-Ph)3P}(Ph3P)]Cl (3) and [Au{(o-MeO-Ph)3P}2]Cl (4) (where o-MeO-Ph)3P = tris(o-methoxyphenyl)phosphane and (Me-Et-Ph)P = methylethylphenylphosphane) were prepared and characterized by elemental analysis, FTIR and NMR spectroscopy. The structure of one of the complexes was determined by X-ray crystallography, which showed that the gold(I) atom is linearly coordinated to the phosphorus and Cl atoms. The in vitro cytotoxicity of the complexes was investigated against four human cancer cell lines; A549, HeLa, MDA-MB-231 and MCF7. In all cases, the tested complexes showed excellent cytotoxicity for the selected cells, with IC50 values much less than cisplatin. In order to know the possible mode of cell death, complex 1 was further evaluated for induction of apoptosis towards the A549 cells. The results indicated that the apoptosis induction increases with the complex concentration.
KW - Anticancer activity
KW - Gold(I)
KW - Phosphanes
KW - X-ray structure
UR - http://www.scopus.com/inward/record.url?scp=85114162284&partnerID=8YFLogxK
U2 - 10.1016/j.ica.2021.120567
DO - 10.1016/j.ica.2021.120567
M3 - Article
AN - SCOPUS:85114162284
SN - 0020-1693
VL - 527
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
M1 - 120567
ER -
