Synthesis and magnetic relaxation properties of new Gd(III) complexes derived from DTPA-bis(amide) conjugates of arylpiperazinyl amines

Abdullah O. Ba-Salem; M. Nasiruzzaman Shaikh; Nisar Ullah; Mohamed Faiz

doi:10.1016/j.inoche.2015.03.042

Synthesis and magnetic relaxation properties of new Gd(III) complexes derived from DTPA-bis(amide) conjugates of arylpiperazinyl amines

Abdullah O. Ba-Salem
, M. Nasiruzzaman Shaikh
, Nisar Ullah^*
, Mohamed Faiz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two new Gd(III) complexes 1 and 2 of the type [Gd(L)H₂O]·nH₂O were synthesized from DTPA-bis(amide) conjugates of arylpiperazinyl amines. The relaxivity (R₁) of these complexes was measured in deionized water, which revealed that complex 2 had a higher relaxivity than 1 and Omniscan®, a commercially available MRI contrast agent. The cytotoxicity studies of 1 and 2 indicated that they are non-toxic which warrant their physiological suitability as potential contrast agents for MRI. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods including elemental analysis, ¹H NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry.

Original language	English
Pages (from-to)	5-7
Number of pages	3
Journal	Inorganic Chemistry Communication
Volume	56
DOIs	https://doi.org/10.1016/j.inoche.2015.03.042
State	Published - 1 Jun 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.

Keywords

Arylpiperizine
DTPA-bis(amide)
Gd(III)-complexes
MRI contrast agents
Relaxivity

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.inoche.2015.03.042

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title = "Synthesis and magnetic relaxation properties of new Gd(III) complexes derived from DTPA-bis(amide) conjugates of arylpiperazinyl amines",

abstract = "Two new Gd(III) complexes 1 and 2 of the type [Gd(L)H2O]·nH2O were synthesized from DTPA-bis(amide) conjugates of arylpiperazinyl amines. The relaxivity (R1) of these complexes was measured in deionized water, which revealed that complex 2 had a higher relaxivity than 1 and Omniscan{\textregistered}, a commercially available MRI contrast agent. The cytotoxicity studies of 1 and 2 indicated that they are non-toxic which warrant their physiological suitability as potential contrast agents for MRI. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods including elemental analysis, 1H NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry.",

keywords = "Arylpiperizine, DTPA-bis(amide), Gd(III)-complexes, MRI contrast agents, Relaxivity",

author = "Ba-Salem, \{Abdullah O.\} and Shaikh, \{M. Nasiruzzaman\} and Nisar Ullah and Mohamed Faiz",

year = "2015",

month = jun,

day = "1",

doi = "10.1016/j.inoche.2015.03.042",

language = "English",

volume = "56",

pages = "5--7",

journal = "Inorganic Chemistry Communication",

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publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Synthesis and magnetic relaxation properties of new Gd(III) complexes derived from DTPA-bis(amide) conjugates of arylpiperazinyl amines

AU - Ba-Salem, Abdullah O.

AU - Shaikh, M. Nasiruzzaman

AU - Ullah, Nisar

AU - Faiz, Mohamed

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Two new Gd(III) complexes 1 and 2 of the type [Gd(L)H2O]·nH2O were synthesized from DTPA-bis(amide) conjugates of arylpiperazinyl amines. The relaxivity (R1) of these complexes was measured in deionized water, which revealed that complex 2 had a higher relaxivity than 1 and Omniscan®, a commercially available MRI contrast agent. The cytotoxicity studies of 1 and 2 indicated that they are non-toxic which warrant their physiological suitability as potential contrast agents for MRI. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods including elemental analysis, 1H NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry.

AB - Two new Gd(III) complexes 1 and 2 of the type [Gd(L)H2O]·nH2O were synthesized from DTPA-bis(amide) conjugates of arylpiperazinyl amines. The relaxivity (R1) of these complexes was measured in deionized water, which revealed that complex 2 had a higher relaxivity than 1 and Omniscan®, a commercially available MRI contrast agent. The cytotoxicity studies of 1 and 2 indicated that they are non-toxic which warrant their physiological suitability as potential contrast agents for MRI. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods including elemental analysis, 1H NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry.

KW - Arylpiperizine

KW - DTPA-bis(amide)

KW - Gd(III)-complexes

KW - MRI contrast agents

KW - Relaxivity

UR - https://www.scopus.com/pages/publications/84925780647

U2 - 10.1016/j.inoche.2015.03.042

DO - 10.1016/j.inoche.2015.03.042

M3 - Article

AN - SCOPUS:84925780647

SN - 1387-7003

VL - 56

SP - 5

EP - 7

JO - Inorganic Chemistry Communication

JF - Inorganic Chemistry Communication

ER -

Synthesis and magnetic relaxation properties of new Gd(III) complexes derived from DTPA-bis(amide) conjugates of arylpiperazinyl amines

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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