Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(III)-complexes supported by a common N-heterocyclic carbene

Lalmohan Jhulki; Parul Dutta; Manas Kumar Santra; Marlon H. Cardoso; Karen G.N. Oshiro; Octávio L. Franco; Valerio Bertolasi; Anvarhusein A. Isab; Christopher W. Bielawski; Joydev Dinda

doi:10.1039/c8nj02008f

Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(III)-complexes supported by a common N-heterocyclic carbene

Lalmohan Jhulki, Parul Dutta, Manas Kumar Santra, Marlon H. Cardoso, Karen G.N. Oshiro, Octávio L. Franco, Valerio Bertolasi, Anvarhusein A. Isab, Christopher W. Bielawski, Joydev Dinda^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The synthesis, structures and anticancer studies of a series of precious metal complexes supported by 1-methyl-2-(phenyl)imidazo[1,5-a]pyridine-2-ylidene (1) have been highlighted. The Ag(i) (2), Au(i) (3) and Au(iii) (4) complexes were prepared using standard methods and characterized by a range of techniques, including NMR spectroscopy, X-ray crystallography and elemental analyses. The in vitro cytotoxicity activities displayed by 2-4 were explored against human colon adenocarcinoma (HCT116), lung cancer (A549) and breast cancer (MCF7) cell lines. A series of assays showed that all of the complexes exhibited significant growth inhibition in the aforementioned cell lines. Inspection of the data collected revealed that the Au(i) and Ag(i) complexes were more potent than their Au(iii) congener, a trend that was found to be consistent with molecular docking studies that utilized BCL-2 as a model as this protein regulates cell death through apoptosis.

Original language	English
Pages (from-to)	13948-13956
Number of pages	9
Journal	New Journal of Chemistry
Volume	42
Issue number	16
DOIs	https://doi.org/10.1039/c8nj02008f
State	Published - 2018

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

ASJC Scopus subject areas

Catalysis
General Chemistry
Materials Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c8nj02008f

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Jhulki, L., Dutta, P., Santra, M. K., Cardoso, M. H., Oshiro, K. G. N., Franco, O. L., Bertolasi, V., Isab, A. A., Bielawski, C. W., & Dinda, J. (2018). Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(III)-complexes supported by a common N-heterocyclic carbene. New Journal of Chemistry, 42(16), 13948-13956. https://doi.org/10.1039/c8nj02008f

@article{2bd17aaf3ae34335a8494ae97c4fdee8,

title = "Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(III)-complexes supported by a common N-heterocyclic carbene",

abstract = "The synthesis, structures and anticancer studies of a series of precious metal complexes supported by 1-methyl-2-(phenyl)imidazo[1,5-a]pyridine-2-ylidene (1) have been highlighted. The Ag(i) (2), Au(i) (3) and Au(iii) (4) complexes were prepared using standard methods and characterized by a range of techniques, including NMR spectroscopy, X-ray crystallography and elemental analyses. The in vitro cytotoxicity activities displayed by 2-4 were explored against human colon adenocarcinoma (HCT116), lung cancer (A549) and breast cancer (MCF7) cell lines. A series of assays showed that all of the complexes exhibited significant growth inhibition in the aforementioned cell lines. Inspection of the data collected revealed that the Au(i) and Ag(i) complexes were more potent than their Au(iii) congener, a trend that was found to be consistent with molecular docking studies that utilized BCL-2 as a model as this protein regulates cell death through apoptosis.",

author = "Lalmohan Jhulki and Parul Dutta and Santra, \{Manas Kumar\} and Cardoso, \{Marlon H.\} and Oshiro, \{Karen G.N.\} and Franco, \{Oct{\'a}vio L.\} and Valerio Bertolasi and Isab, \{Anvarhusein A.\} and Bielawski, \{Christopher W.\} and Joydev Dinda",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.",

year = "2018",

doi = "10.1039/c8nj02008f",

language = "English",

volume = "42",

pages = "13948--13956",

journal = "New Journal of Chemistry",

issn = "1144-0546",

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Jhulki, L, Dutta, P, Santra, MK, Cardoso, MH, Oshiro, KGN, Franco, OL, Bertolasi, V, Isab, AA, Bielawski, CW & Dinda, J 2018, 'Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(III)-complexes supported by a common N-heterocyclic carbene', New Journal of Chemistry, vol. 42, no. 16, pp. 13948-13956. https://doi.org/10.1039/c8nj02008f

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T1 - Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(III)-complexes supported by a common N-heterocyclic carbene

AU - Jhulki, Lalmohan

AU - Dutta, Parul

AU - Santra, Manas Kumar

AU - Cardoso, Marlon H.

AU - Oshiro, Karen G.N.

AU - Franco, Octávio L.

AU - Bertolasi, Valerio

AU - Isab, Anvarhusein A.

AU - Bielawski, Christopher W.

AU - Dinda, Joydev

PY - 2018

Y1 - 2018

N2 - The synthesis, structures and anticancer studies of a series of precious metal complexes supported by 1-methyl-2-(phenyl)imidazo[1,5-a]pyridine-2-ylidene (1) have been highlighted. The Ag(i) (2), Au(i) (3) and Au(iii) (4) complexes were prepared using standard methods and characterized by a range of techniques, including NMR spectroscopy, X-ray crystallography and elemental analyses. The in vitro cytotoxicity activities displayed by 2-4 were explored against human colon adenocarcinoma (HCT116), lung cancer (A549) and breast cancer (MCF7) cell lines. A series of assays showed that all of the complexes exhibited significant growth inhibition in the aforementioned cell lines. Inspection of the data collected revealed that the Au(i) and Ag(i) complexes were more potent than their Au(iii) congener, a trend that was found to be consistent with molecular docking studies that utilized BCL-2 as a model as this protein regulates cell death through apoptosis.

AB - The synthesis, structures and anticancer studies of a series of precious metal complexes supported by 1-methyl-2-(phenyl)imidazo[1,5-a]pyridine-2-ylidene (1) have been highlighted. The Ag(i) (2), Au(i) (3) and Au(iii) (4) complexes were prepared using standard methods and characterized by a range of techniques, including NMR spectroscopy, X-ray crystallography and elemental analyses. The in vitro cytotoxicity activities displayed by 2-4 were explored against human colon adenocarcinoma (HCT116), lung cancer (A549) and breast cancer (MCF7) cell lines. A series of assays showed that all of the complexes exhibited significant growth inhibition in the aforementioned cell lines. Inspection of the data collected revealed that the Au(i) and Ag(i) complexes were more potent than their Au(iii) congener, a trend that was found to be consistent with molecular docking studies that utilized BCL-2 as a model as this protein regulates cell death through apoptosis.

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DO - 10.1039/c8nj02008f

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SN - 1144-0546

VL - 42

SP - 13948

EP - 13956

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 16

ER -

Synthesis and cytotoxic characteristics displayed by a series of Ag(i)-, Au(i)- and Au(III)-complexes supported by a common N-heterocyclic carbene

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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