Synthesis and characterization of novel amphiphilic biocompatible block-copolymers of poly(N-isopropylacrylamide)-b-poly(L-phenylalanine methyl ester) by RAFT polymerization

Chandra Sekhar Biswas; Arpan Biswas; Massimillano Galluzzi; Mehdihasan I. Shekh; Qiao Wang; Biswajit Ray; Pralay Maiti; Florian J. Stadler

doi:10.1016/j.polymer.2020.122760

Synthesis and characterization of novel amphiphilic biocompatible block-copolymers of poly(N-isopropylacrylamide)-b-poly(L-phenylalanine methyl ester) by RAFT polymerization

Chandra Sekhar Biswas, Arpan Biswas, Massimillano Galluzzi, Mehdihasan I. Shekh, Qiao Wang, Biswajit Ray, Pralay Maiti, Florian J. Stadler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The synthesis of amphiphilic block-copolymers of poly(N-isopropylacrylamide) (PNIPAM) and poly(N-acryloyl-L-phenylalanine methyl ester) (PNALPA) by RAFT polymerization is reported. The polymers were characterized by proton NMR (¹H NMR), gel permeation chromatography (GPC), powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA) to understand their structure-property relationships. All synthesized polymers show pH triggered release at acidic (pH 5) and biological pH (pH 7.4). Critical micellar concentration also varied systematically depending on the amphiphilic nature of the polymers. Biocompatibilities of the polymers are also determined to check their suitability for biomedical applications.

Original language	English
Article number	122760
Journal	Polymer
Volume	203
DOIs	https://doi.org/10.1016/j.polymer.2020.122760
State	Published - 26 Aug 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

Keywords

Amino acids
Amphiphilic block copolymers
Biocompatibility
Drug delivery
Stimuli responsiveness

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.polymer.2020.122760

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@article{fa966d662eb74a639abf67918e69e2b0,

title = "Synthesis and characterization of novel amphiphilic biocompatible block-copolymers of poly(N-isopropylacrylamide)-b-poly(L-phenylalanine methyl ester) by RAFT polymerization",

abstract = "The synthesis of amphiphilic block-copolymers of poly(N-isopropylacrylamide) (PNIPAM) and poly(N-acryloyl-L-phenylalanine methyl ester) (PNALPA) by RAFT polymerization is reported. The polymers were characterized by proton NMR (1H NMR), gel permeation chromatography (GPC), powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA) to understand their structure-property relationships. All synthesized polymers show pH triggered release at acidic (pH 5) and biological pH (pH 7.4). Critical micellar concentration also varied systematically depending on the amphiphilic nature of the polymers. Biocompatibilities of the polymers are also determined to check their suitability for biomedical applications.",

keywords = "Amino acids, Amphiphilic block copolymers, Biocompatibility, Drug delivery, Stimuli responsiveness",

author = "Biswas, \{Chandra Sekhar\} and Arpan Biswas and Massimillano Galluzzi and Shekh, \{Mehdihasan I.\} and Qiao Wang and Biswajit Ray and Pralay Maiti and Stadler, \{Florian J.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = aug,

day = "26",

doi = "10.1016/j.polymer.2020.122760",

language = "English",

volume = "203",

journal = "Polymer",

issn = "0032-3861",

}

TY - JOUR

T1 - Synthesis and characterization of novel amphiphilic biocompatible block-copolymers of poly(N-isopropylacrylamide)-b-poly(L-phenylalanine methyl ester) by RAFT polymerization

AU - Biswas, Chandra Sekhar

AU - Biswas, Arpan

AU - Galluzzi, Massimillano

AU - Shekh, Mehdihasan I.

AU - Wang, Qiao

AU - Ray, Biswajit

AU - Maiti, Pralay

AU - Stadler, Florian J.

PY - 2020/8/26

Y1 - 2020/8/26

N2 - The synthesis of amphiphilic block-copolymers of poly(N-isopropylacrylamide) (PNIPAM) and poly(N-acryloyl-L-phenylalanine methyl ester) (PNALPA) by RAFT polymerization is reported. The polymers were characterized by proton NMR (1H NMR), gel permeation chromatography (GPC), powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA) to understand their structure-property relationships. All synthesized polymers show pH triggered release at acidic (pH 5) and biological pH (pH 7.4). Critical micellar concentration also varied systematically depending on the amphiphilic nature of the polymers. Biocompatibilities of the polymers are also determined to check their suitability for biomedical applications.

AB - The synthesis of amphiphilic block-copolymers of poly(N-isopropylacrylamide) (PNIPAM) and poly(N-acryloyl-L-phenylalanine methyl ester) (PNALPA) by RAFT polymerization is reported. The polymers were characterized by proton NMR (1H NMR), gel permeation chromatography (GPC), powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA) to understand their structure-property relationships. All synthesized polymers show pH triggered release at acidic (pH 5) and biological pH (pH 7.4). Critical micellar concentration also varied systematically depending on the amphiphilic nature of the polymers. Biocompatibilities of the polymers are also determined to check their suitability for biomedical applications.

KW - Amino acids

KW - Amphiphilic block copolymers

KW - Biocompatibility

KW - Drug delivery

KW - Stimuli responsiveness

UR - https://www.scopus.com/pages/publications/85088821157

U2 - 10.1016/j.polymer.2020.122760

DO - 10.1016/j.polymer.2020.122760

M3 - Article

AN - SCOPUS:85088821157

SN - 0032-3861

VL - 203

JO - Polymer

JF - Polymer

M1 - 122760

ER -

Synthesis and characterization of novel amphiphilic biocompatible block-copolymers of poly(N-isopropylacrylamide)-b-poly(L-phenylalanine methyl ester) by RAFT polymerization

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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