TY - JOUR
T1 - Synthesis and characterization of complexes of trialkyl- and triarylphosphine gold(I) with thiolated purines and pyrimidines
T2 - a class of bifunctional compounds with potential antitumor activity
AU - Stocco, Giancarlo
AU - Gattuso, Filippa
AU - Isab, Anvarhusein A.
AU - Shaw, C. Frank
PY - 1993/7/15
Y1 - 1993/7/15
N2 - New complexes of the type R3PAuL or (R3PAu)2(μ-L) where R=ethyl or phenyl and L=6-thioguanine, 2, 6- dithioxanthine, 2, 4-dithiouracil and/or dithioerythritol have been prepared. These complexes have been identified by using elemental analysis, 1H, 13C and 31P NMR spectroscopy. The structures have been proposed based on these spectroscopic studies. Sulfur appears to be the binding site in disubstituted complexes of 2, 4-dithiouracil and 1, 4-dithioerythritol, while the phosphine gold(I) moieties appear to be S and N bonded in 2, 6-dithioxanthine and 6-thioguanine. The potential use of these complexes as antitumor drugs is discussed.
AB - New complexes of the type R3PAuL or (R3PAu)2(μ-L) where R=ethyl or phenyl and L=6-thioguanine, 2, 6- dithioxanthine, 2, 4-dithiouracil and/or dithioerythritol have been prepared. These complexes have been identified by using elemental analysis, 1H, 13C and 31P NMR spectroscopy. The structures have been proposed based on these spectroscopic studies. Sulfur appears to be the binding site in disubstituted complexes of 2, 4-dithiouracil and 1, 4-dithioerythritol, while the phosphine gold(I) moieties appear to be S and N bonded in 2, 6-dithioxanthine and 6-thioguanine. The potential use of these complexes as antitumor drugs is discussed.
UR - https://www.scopus.com/pages/publications/0000062503
U2 - 10.1016/S0020-1693(00)85133-6
DO - 10.1016/S0020-1693(00)85133-6
M3 - Article
AN - SCOPUS:0000062503
SN - 0020-1693
VL - 209
SP - 129
EP - 135
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
IS - 2
ER -