Surface modification and cytotoxicity of Mg-based bio-alloys: An overview of recent advances

Murad Ali*, Mohamed Elsherif, Ahmed E. Salih, Anwar Ul-Hamid, M. A. Hussein, Seongjun Park, Ali K. Yetisen, Haider Butt

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


The use of magnesium and its alloys for bone implants, cardiovascular stents, and wound closing devices have received considerable attention recently, however, their rapid degradation remains a major concern. Mg-based alloys degrade in the body prior to the completion of their specified healing period. Various biocompatible coatings have been used to overcome this shortcoming and to improve the surface properties such as hardness, corrosion resistance, and biocompatibility. The biocompatible materials used include calcium phosphate (Ca–P), hydroxyapatite (HA), octa calcium phosphate (Octa-Ca-P), metals (Zr, N, Hf, Nd, Zn, Cr, O, Ti), metal oxides (Al2O3, ZrO2, Cr2O3, SiO2, TiO2, Ta2O5, MgO), fluorides, and biopolymers. This paper reviews the surface treatment techniques utilized for Mg and Mg alloys. Additionally, related problems and possible solutions for Mg-based alloys with cytotoxicity are discussed.

Original languageEnglish
Article number154140
JournalJournal of Alloys and Compounds
StatePublished - 5 Jun 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier B.V.


  • Biocompatibility
  • Biomedical applications
  • Coating
  • Corrosion
  • Magnesium

ASJC Scopus subject areas

  • Mechanics of Materials
  • Mechanical Engineering
  • Metals and Alloys
  • Materials Chemistry


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