1H, 13C NMR and UV spectroscopy studies of gold(III)-tetracyanide complex with l-cysteine, glutathione, captopril, l-methionine and dl-seleno-methionine in aqueous solution

Bassem A. Al-Maythalony; Mohamed I.M. Wazeer; Anvarhusein A. Isab

doi:10.1016/j.ica.2010.06.001

¹H, ¹³C NMR and UV spectroscopy studies of gold(III)-tetracyanide complex with l-cysteine, glutathione, captopril, l-methionine and dl-seleno-methionine in aqueous solution

Bassem A. Al-Maythalony, Mohamed I.M. Wazeer, Anvarhusein A. Isab

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Auricyanide [Au(CN)₄]^- interaction with biologically important thiols, thioether and selenoether were carried out and monitored using ¹H, ¹³C NMR and UV spectroscopy. These ligands include l-cysteine, glutathione, captopril, l-methionine and dl-seleno-methionine. Thiols show very strong affinity to be oxidized into the disulfide by auricyanide, which gets reduced to aurocyanide [Au(CN)₂]^-. l-cysteine reaction mechanism with [Au(CN)₄]^- was found to be dependent on reactants mole ratio. While l-methionine was completely inert toward auricyanide, dl-Se-methionine showed some reactivity with [Au(CN) ₄]^- after raising solution pH to 12 that facilitated cyanide exchange.

Original language	English
Pages (from-to)	3244-3253
Number of pages	10
Journal	Inorganica Chimica Acta
Volume	363
Issue number	13
DOIs	https://doi.org/10.1016/j.ica.2010.06.001
State	Published - 25 Oct 2010

Bibliographical note

Funding Information:
The authors would like to acknowledge the support by the Deanship of Scientific Research at King Fahd University of Petroleum and Minerals for funding this work through project No. ( IN080421 ). We also thank the Squibb Institute for Medical Research, Princeton, NJ, USA for their generous gift of captopril.

Keywords

Au(III)-tetracyanide complexes
Thiols
UV-Vis
dl-seleno-methionine
l-methionine

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1016/j.ica.2010.06.001

Cite this

@article{dda0a96ea58d4767b26802f0aca4e2b7,

title = "1H, 13C NMR and UV spectroscopy studies of gold(III)-tetracyanide complex with l-cysteine, glutathione, captopril, l-methionine and dl-seleno-methionine in aqueous solution",

abstract = "Auricyanide [Au(CN)4]- interaction with biologically important thiols, thioether and selenoether were carried out and monitored using 1H, 13C NMR and UV spectroscopy. These ligands include l-cysteine, glutathione, captopril, l-methionine and dl-seleno-methionine. Thiols show very strong affinity to be oxidized into the disulfide by auricyanide, which gets reduced to aurocyanide [Au(CN)2]-. l-cysteine reaction mechanism with [Au(CN)4]- was found to be dependent on reactants mole ratio. While l-methionine was completely inert toward auricyanide, dl-Se-methionine showed some reactivity with [Au(CN) 4]- after raising solution pH to 12 that facilitated cyanide exchange.",

keywords = "Au(III)-tetracyanide complexes, Thiols, UV-Vis, dl-seleno-methionine, l-methionine",

author = "Al-Maythalony, \{Bassem A.\} and Wazeer, \{Mohamed I.M.\} and Isab, \{Anvarhusein A.\}",

note = "Funding Information: The authors would like to acknowledge the support by the Deanship of Scientific Research at King Fahd University of Petroleum and Minerals for funding this work through project No. ( IN080421 ). We also thank the Squibb Institute for Medical Research, Princeton, NJ, USA for their generous gift of captopril.",

year = "2010",

month = oct,

day = "25",

doi = "10.1016/j.ica.2010.06.001",

language = "English",

volume = "363",

pages = "3244--3253",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

number = "13",

}

¹H, ¹³C NMR and UV spectroscopy studies of gold(III)-tetracyanide complex with l-cysteine, glutathione, captopril, l-methionine and dl-seleno-methionine in aqueous solution. / Al-Maythalony, Bassem A.; Wazeer, Mohamed I.M.; Isab, Anvarhusein A.
In: Inorganica Chimica Acta, Vol. 363, No. 13, 25.10.2010, p. 3244-3253.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - 1H, 13C NMR and UV spectroscopy studies of gold(III)-tetracyanide complex with l-cysteine, glutathione, captopril, l-methionine and dl-seleno-methionine in aqueous solution

AU - Al-Maythalony, Bassem A.

AU - Wazeer, Mohamed I.M.

AU - Isab, Anvarhusein A.

N1 - Funding Information: The authors would like to acknowledge the support by the Deanship of Scientific Research at King Fahd University of Petroleum and Minerals for funding this work through project No. ( IN080421 ). We also thank the Squibb Institute for Medical Research, Princeton, NJ, USA for their generous gift of captopril.

PY - 2010/10/25

Y1 - 2010/10/25

N2 - Auricyanide [Au(CN)4]- interaction with biologically important thiols, thioether and selenoether were carried out and monitored using 1H, 13C NMR and UV spectroscopy. These ligands include l-cysteine, glutathione, captopril, l-methionine and dl-seleno-methionine. Thiols show very strong affinity to be oxidized into the disulfide by auricyanide, which gets reduced to aurocyanide [Au(CN)2]-. l-cysteine reaction mechanism with [Au(CN)4]- was found to be dependent on reactants mole ratio. While l-methionine was completely inert toward auricyanide, dl-Se-methionine showed some reactivity with [Au(CN) 4]- after raising solution pH to 12 that facilitated cyanide exchange.

AB - Auricyanide [Au(CN)4]- interaction with biologically important thiols, thioether and selenoether were carried out and monitored using 1H, 13C NMR and UV spectroscopy. These ligands include l-cysteine, glutathione, captopril, l-methionine and dl-seleno-methionine. Thiols show very strong affinity to be oxidized into the disulfide by auricyanide, which gets reduced to aurocyanide [Au(CN)2]-. l-cysteine reaction mechanism with [Au(CN)4]- was found to be dependent on reactants mole ratio. While l-methionine was completely inert toward auricyanide, dl-Se-methionine showed some reactivity with [Au(CN) 4]- after raising solution pH to 12 that facilitated cyanide exchange.

KW - Au(III)-tetracyanide complexes

KW - Thiols

KW - UV-Vis

KW - dl-seleno-methionine

KW - l-methionine

UR - https://www.scopus.com/pages/publications/77957697009

U2 - 10.1016/j.ica.2010.06.001

DO - 10.1016/j.ica.2010.06.001

M3 - Article

AN - SCOPUS:77957697009

SN - 0020-1693

VL - 363

SP - 3244

EP - 3253

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

IS - 13

ER -