13C nuclear magnetic resonance detection of thiol exchange on gold(I): Significance in chemotherapy

Anvarhusein A. Isab; Peter J. Sadler

doi:10.1039/C3976001051b

¹³C nuclear magnetic resonance detection of thiol exchange on gold(I): Significance in chemotherapy

Anvarhusein A. Isab
, Peter J. Sadler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Thiols such as N-acetyl-L-cysteine react with aurothiomalate in aqueous solution at pH 7 to give Au₄(SR)₇^3- clusters which undergo fast exchange with RS^- but not RSH.

Original language	English
Pages (from-to)	1051b-1052
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	24
DOIs	https://doi.org/10.1039/C3976001051b
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

Access to Document

10.1039/C3976001051b

Cite this

@article{3d7dd89d9f4045a89b223c7aa56ff23a,

title = "13C nuclear magnetic resonance detection of thiol exchange on gold(I): Significance in chemotherapy",

abstract = "Thiols such as N-acetyl-L-cysteine react with aurothiomalate in aqueous solution at pH 7 to give Au4(SR)73- clusters which undergo fast exchange with RS- but not RSH.",

author = "Isab, \{Anvarhusein A.\} and Sadler, \{Peter J.\}",

year = "1976",

doi = "10.1039/C3976001051b",

language = "English",

pages = "1051b--1052",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

publisher = "Chemical Society",

number = "24",

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TY - JOUR

T1 - 13C nuclear magnetic resonance detection of thiol exchange on gold(I)

T2 - Significance in chemotherapy

AU - Isab, Anvarhusein A.

AU - Sadler, Peter J.

PY - 1976

Y1 - 1976

N2 - Thiols such as N-acetyl-L-cysteine react with aurothiomalate in aqueous solution at pH 7 to give Au4(SR)73- clusters which undergo fast exchange with RS- but not RSH.

AB - Thiols such as N-acetyl-L-cysteine react with aurothiomalate in aqueous solution at pH 7 to give Au4(SR)73- clusters which undergo fast exchange with RS- but not RSH.

UR - https://www.scopus.com/pages/publications/37049103832

U2 - 10.1039/C3976001051b

DO - 10.1039/C3976001051b

M3 - Article

AN - SCOPUS:37049103832

SN - 0022-4936

SP - 1051b-1052

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 24