13C-n.m.r. studies of the binding of 1,3-diazinane-2-selenone and 1,3-diazipine-2-selenone to gold(I) drugs

Anvarhusein A. Isab; Saeed Ahmad; Waqar Ashraf

doi:10.1007/s11243-004-6966-3

¹³C-n.m.r. studies of the binding of 1,3-diazinane-2-selenone and 1,3-diazipine-2-selenone to gold(I) drugs

Anvarhusein A. Isab^*
, Saeed Ahmad
, Waqar Ashraf

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The interaction of gold(I) thiomalate, Myocrisin [(Autm) _n ] with 1,3-diazinane-2-selenone (DiazSe) and 1,3-diazipine-2-selenone (DiapSe) has been studied in aqueous solution using ¹³C-n.m.r. spectroscopy. It is observed that ternary complexes, (DiazSe-Au-tm and DiapSe-Au-tm, respectively) are formed on coordination of these ligands to (Autm) _n . The ¹³C-n.m.r. data suggest that DiapSe binds more strongly to (Autm) _n than does DiazSe, which binds more strongly compared to its analogous thione, 1,3-diazinane-2-thione (Diaz). A similar observation was made for the gold(I) thioglucose (Autg) reaction with DiazSe.

Original language	English
Pages (from-to)	389-392
Number of pages	4
Journal	Transition Metal Chemistry
Volume	30
Issue number	4
DOIs	https://doi.org/10.1007/s11243-004-6966-3
State	Published - May 2005

Bibliographical note

Funding Information:
This research was supported by the KFUPM Research Committee under project No. SABIC 2003–08.

ASJC Scopus subject areas

Inorganic Chemistry
Metals and Alloys
Materials Chemistry

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10.1007/s11243-004-6966-3

Cite this

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title = "13C-n.m.r. studies of the binding of 1,3-diazinane-2-selenone and 1,3-diazipine-2-selenone to gold(I) drugs",

abstract = "The interaction of gold(I) thiomalate, Myocrisin [(Autm) n ] with 1,3-diazinane-2-selenone (DiazSe) and 1,3-diazipine-2-selenone (DiapSe) has been studied in aqueous solution using 13C-n.m.r. spectroscopy. It is observed that ternary complexes, (DiazSe-Au-tm and DiapSe-Au-tm, respectively) are formed on coordination of these ligands to (Autm) n . The 13C-n.m.r. data suggest that DiapSe binds more strongly to (Autm) n than does DiazSe, which binds more strongly compared to its analogous thione, 1,3-diazinane-2-thione (Diaz). A similar observation was made for the gold(I) thioglucose (Autg) reaction with DiazSe.",

author = "Isab, \{Anvarhusein A.\} and Saeed Ahmad and Waqar Ashraf",

note = "Funding Information: This research was supported by the KFUPM Research Committee under project No. SABIC 2003{\textendash}08.",

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doi = "10.1007/s11243-004-6966-3",

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T1 - 13C-n.m.r. studies of the binding of 1,3-diazinane-2-selenone and 1,3-diazipine-2-selenone to gold(I) drugs

AU - Isab, Anvarhusein A.

AU - Ahmad, Saeed

AU - Ashraf, Waqar

N1 - Funding Information: This research was supported by the KFUPM Research Committee under project No. SABIC 2003–08.

PY - 2005/5

Y1 - 2005/5

N2 - The interaction of gold(I) thiomalate, Myocrisin [(Autm) n ] with 1,3-diazinane-2-selenone (DiazSe) and 1,3-diazipine-2-selenone (DiapSe) has been studied in aqueous solution using 13C-n.m.r. spectroscopy. It is observed that ternary complexes, (DiazSe-Au-tm and DiapSe-Au-tm, respectively) are formed on coordination of these ligands to (Autm) n . The 13C-n.m.r. data suggest that DiapSe binds more strongly to (Autm) n than does DiazSe, which binds more strongly compared to its analogous thione, 1,3-diazinane-2-thione (Diaz). A similar observation was made for the gold(I) thioglucose (Autg) reaction with DiazSe.

AB - The interaction of gold(I) thiomalate, Myocrisin [(Autm) n ] with 1,3-diazinane-2-selenone (DiazSe) and 1,3-diazipine-2-selenone (DiapSe) has been studied in aqueous solution using 13C-n.m.r. spectroscopy. It is observed that ternary complexes, (DiazSe-Au-tm and DiapSe-Au-tm, respectively) are formed on coordination of these ligands to (Autm) n . The 13C-n.m.r. data suggest that DiapSe binds more strongly to (Autm) n than does DiazSe, which binds more strongly compared to its analogous thione, 1,3-diazinane-2-thione (Diaz). A similar observation was made for the gold(I) thioglucose (Autg) reaction with DiazSe.

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DO - 10.1007/s11243-004-6966-3

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