13C and 15N NMR studies of the interaction of gold(I) captopril with selenocyanate, selenourea, and thiourea in aqueous solution

M. Naseem Akhtar; Anvarhusein A. Isab; Abdul Rahman Al-Arfaj

doi:10.1016/S0162-0134(96)00205-X

¹³C and ¹⁵N NMR studies of the interaction of gold(I) captopril with selenocyanate, selenourea, and thiourea in aqueous solution

M. Naseem Akhtar, Anvarhusein A. Isab^*, Abdul Rahman Al-Arfaj

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The interaction of KSe¹³ C¹⁵N with gold(I)-captopril (Aucap)(n) in aqueous solution was studied by ¹³C and ¹⁵N NMR spectroscopy. The Se¹³C¹⁵N^- interacts with (Aucap)(n) to form an unstable [cap-Au- Se¹³C¹⁵N]^- species which readily undergoes disproportionation and redox reactions to generate [Au(¹³C¹⁵N)₂]^-, (cap)₂, Se⁰, and Au⁰. The approximate second-order rate constant of disproportionation of [cap-Au- Se¹³C¹⁵N]^- is found to be 0.014 ± 0.001 1 mol^-1 h^-1. The ¹³C and ¹⁵N chemical shifts and ¹J(⁷⁷Se-¹³C) and ¹J(¹³C-¹⁵N) coupling constants for free Se¹³C¹⁵N^- and [Au(¹³C¹⁵N)₂]^- species are reported. The interaction of selenourea (SeU) with (Aucap)(n) resulted in the formation of a [cap-Au-SeU] complex which underwent decomposition and redox reactions to produce (cap)₂, Se⁰, and Au⁰ species. Thiourea gave rise to a stable [cap-Au-TU] complex which did not undergo redox reaction.

Original language	English
Pages (from-to)	197-205
Number of pages	9
Journal	Journal of Inorganic Biochemistry
Volume	66
Issue number	3
DOIs	https://doi.org/10.1016/S0162-0134(96)00205-X
State	Published - 15 May 1997

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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10.1016/S0162-0134(96)00205-X

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@article{ce4b431ddae74b989dfafaed1dba8579,

title = "13C and 15N NMR studies of the interaction of gold(I) captopril with selenocyanate, selenourea, and thiourea in aqueous solution",

abstract = "The interaction of KSe13 C15N with gold(I)-captopril (Aucap)(n) in aqueous solution was studied by 13C and 15N NMR spectroscopy. The Se13C15N- interacts with (Aucap)(n) to form an unstable [cap-Au- Se13C15N]- species which readily undergoes disproportionation and redox reactions to generate [Au(13C15N)2]-, (cap)2, Se0, and Au0. The approximate second-order rate constant of disproportionation of [cap-Au- Se13C15N]- is found to be 0.014 ± 0.001 1 mol-1 h-1. The 13C and 15N chemical shifts and 1J(77Se-13C) and 1J(13C-15N) coupling constants for free Se13C15N- and [Au(13C15N)2]- species are reported. The interaction of selenourea (SeU) with (Aucap)(n) resulted in the formation of a [cap-Au-SeU] complex which underwent decomposition and redox reactions to produce (cap)2, Se0, and Au0 species. Thiourea gave rise to a stable [cap-Au-TU] complex which did not undergo redox reaction.",

author = "Akhtar, \{M. Naseem\} and Isab, \{Anvarhusein A.\} and Al-Arfaj, \{Abdul Rahman\}",

year = "1997",

month = may,

day = "15",

doi = "10.1016/S0162-0134(96)00205-X",

language = "English",

volume = "66",

pages = "197--205",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

number = "3",

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TY - JOUR

T1 - 13C and 15N NMR studies of the interaction of gold(I) captopril with selenocyanate, selenourea, and thiourea in aqueous solution

AU - Akhtar, M. Naseem

AU - Isab, Anvarhusein A.

AU - Al-Arfaj, Abdul Rahman

PY - 1997/5/15

Y1 - 1997/5/15

N2 - The interaction of KSe13 C15N with gold(I)-captopril (Aucap)(n) in aqueous solution was studied by 13C and 15N NMR spectroscopy. The Se13C15N- interacts with (Aucap)(n) to form an unstable [cap-Au- Se13C15N]- species which readily undergoes disproportionation and redox reactions to generate [Au(13C15N)2]-, (cap)2, Se0, and Au0. The approximate second-order rate constant of disproportionation of [cap-Au- Se13C15N]- is found to be 0.014 ± 0.001 1 mol-1 h-1. The 13C and 15N chemical shifts and 1J(77Se-13C) and 1J(13C-15N) coupling constants for free Se13C15N- and [Au(13C15N)2]- species are reported. The interaction of selenourea (SeU) with (Aucap)(n) resulted in the formation of a [cap-Au-SeU] complex which underwent decomposition and redox reactions to produce (cap)2, Se0, and Au0 species. Thiourea gave rise to a stable [cap-Au-TU] complex which did not undergo redox reaction.

AB - The interaction of KSe13 C15N with gold(I)-captopril (Aucap)(n) in aqueous solution was studied by 13C and 15N NMR spectroscopy. The Se13C15N- interacts with (Aucap)(n) to form an unstable [cap-Au- Se13C15N]- species which readily undergoes disproportionation and redox reactions to generate [Au(13C15N)2]-, (cap)2, Se0, and Au0. The approximate second-order rate constant of disproportionation of [cap-Au- Se13C15N]- is found to be 0.014 ± 0.001 1 mol-1 h-1. The 13C and 15N chemical shifts and 1J(77Se-13C) and 1J(13C-15N) coupling constants for free Se13C15N- and [Au(13C15N)2]- species are reported. The interaction of selenourea (SeU) with (Aucap)(n) resulted in the formation of a [cap-Au-SeU] complex which underwent decomposition and redox reactions to produce (cap)2, Se0, and Au0 species. Thiourea gave rise to a stable [cap-Au-TU] complex which did not undergo redox reaction.

UR - https://www.scopus.com/pages/publications/0030937885

U2 - 10.1016/S0162-0134(96)00205-X

DO - 10.1016/S0162-0134(96)00205-X

M3 - Article

AN - SCOPUS:0030937885

SN - 0162-0134

VL - 66

SP - 197

EP - 205

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 3